2. Gene
  3. DHX58 - DExH-box helicase 58 Gene

DHX58 - DExH-box helicase 58 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DExH-box 解旋酶 58

种属: Homo sapiens

同用名: LGP2; RLR-3; D11LGP2; D11lgp2e

基因 ID: 79132 | 基因类型: protein coding

关于 DHX58

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,101,411-42,112,714 (from NCBI)

This gene has 8 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues.

功能概要

启用双链 RNA 结合活性；单链 RNA 结合活性；和锌离子结合活性。参与防御反应的负调节和 I 型干扰素产生的负调节。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DHX58 基因产物(1)

mRNA Protein Name
NM_024119.3 NP_077024.2 ATP-dependent RNA helicase DHX58
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IMP
IMP: 通过突变表型推断
19211564 GOA
enables RNA helicase activity IMP
IMP: 通过突变表型推断
19211564 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
18411269 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17190814 GOA
enables single-stranded RNA binding IDA
IDA: 通过直接分析推断
18411269 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
19278996 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic pattern recognition receptor signaling pathway IMP
IMP: 通过突变表型推断
19211564 GOA
involved in negative regulation of MDA-5 signaling pathway IMP
IMP: 通过突变表型推断
21187438 GOA
involved in negative regulation of RIG-I signaling pathway IDA
IDA: 通过直接分析推断
18411269 GOA
involved in negative regulation of RIG-I signaling pathway IMP
IMP: 通过突变表型推断
21187438 GOA
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
21525357 GOA
involved in negative regulation of type I interferon production IDA
IDA: 通过直接分析推断
21525357 GOA
involved in regulation of innate immune response IDA
IDA: 通过直接分析推断
18411269 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHX58 蛋白结构

ResIII

ResIII: Type III restriction enzyme, res subunit (1 - 170)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (414 - 473)

RIG-I_C-RD

RIG-I_C-RD: C-terminal domain of RIG-I (550 - 670)

  • 0
  • 200
  • 400
  • 600
  • 678 a.a.
蛋白主名 其他名称

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2

DHX58 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DHX58 Q96C10 DHX30 Homo sapiens Q7L2E3
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 EIF6 Homo sapiens P56537
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 DICER1 Homo sapiens Q9UPY3
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 EIF2AK2 Homo sapiens P19525
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 STAU2 Homo sapiens Q9NUL3
Anti Tag CoIP
21903422
种属内
DHX58 Q96C10 NKRF Homo sapiens O15226
Anti Tag CoIP
21903422
种属间
DHX58 Q96C10 P/V Simian virus 5 P11207
Anti Tag CoIP
19403670
种属间
DHX58 Q96C10 P/V Measles virus Q9EMA9
Anti Tag CoIP
19403670
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots
Rabies

Lyssa

Hydrophobia

St Hubert Disease
Ileum Cancer

Ileal Neoplasm

Malignant Neoplasm Of Ileum

Ileal Cancer

Ileal Neoplasms
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Keratitis, Hereditary

Keratitis

Autosomal Dominant Keratitis

Hereditary Keratitis

Dominantly Inherited Keratitis

Keratitis Hereditary

KERH
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03759 DHX58 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DHX58 VGNC VGNC:39951
Rattus norvegicus DHX58 RGD RGD:1310093
Macaca mulatta DHX58 VGNC VGNC:71815
Mus musculus DHX58 MGD MGI:1931560
Felis catus DHX58 VGNC VGNC:61486
Bos taurus DHX58 VGNC VGNC:28058
Others DHX58 NCBI
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