IL15RA - interleukin 15 receptor subunit alpha Gene

中文名称：白介素 15 受体亚基 α

种属: Homo sapiens

同用名: CD215

关于 IL15RA

功能概要

该基因编码一种细胞因子受体，它以高亲和力特异性结合白细胞介素 15 (IL15) 。 IL15 和 IL2 的受体共享两个亚基，IL2R beta 和 IL2R gamma。这形成了 IL15 和 IL2 的许多重叠生物活性的基础。由该基因编码的蛋白质在结构上与 IL2R α 相关，IL2R α 是高亲和力 IL2 结合所必需的额外 IL2 特异性 α 亚基。与 IL2RA 不同，IL15RA 能够独立于其他亚基以高亲和力结合 IL15，这表明 IL15 和 IL2 之间具有不同的作用。据报道，该受体可增强细胞增殖和细胞凋亡抑制剂 BCL2L1/BCL2-XL 和 BCL2 的表达。已经报道了该基因的多个可变剪接转录本变体。[RefSeq 提供，2010 年 4 月]

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of Apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]