Idh2 - isocitrate dehydrogenase (NADP(+)) 2 Gene

中文名称：异柠檬酸脱氢酶 (NADP (+)) 2

种属: Rattus norvegicus

关于 Idh2

功能概要

该基因编码的蛋白可启动异柠檬酸脱氢酶 (NADP+) 活性。涉及多个过程，包括NADP生物合成过程；神经胶质细胞增殖的负调节；基质金属肽酶分泌的负调控。预测位于胞质溶胶和过氧化物酶体中。预测在线粒体中活跃。用于研究癫痫持续状态。涉及 D-2-羟基戊二酸尿症 2 的该基因的人类直系同源物；急性髓性白血病；癌（多发性）；和肺癌（多发）。与人类 IDH2（异柠檬酸脱氢酶 (NADP(+)) 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables isocitrate dehydrogenase (NADP+) activity. Involved in several processes, including NADP biosynthetic process; negative regulation of glial cell proliferation; and negative regulation of matrix metallopeptidase secretion. Predicted to be located in cytosol and peroxisome. Predicted to be active in mitochondrion. Used to study status epilepticus. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]