2. Gene
  3. Prmt5 - protein arginine methyltransferase 5 Gene

Prmt5 - protein arginine methyltransferase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白质精氨酸甲基转移酶 5

种属: Rattus norvegicus

同用名: Skb1; Hrmt1l5

基因 ID: 364382 | 基因类型: protein coding

关于 Prmt5

Primary_assembly 15: 27,968,910-27,978,296 reverse strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 9 phenotypes. Biased expression in Kidney (RPKM 128.5), Brain (RPKM 19.8) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 p53 绑定活动；蛋白质-精氨酸 N-甲基转移酶活性；和序列特异性 DNA 结合活性。参与多个过程，包括肝再生；少突胶质细胞分化的正调节； ERK1 和 ERK2 级联的调节。部分含蛋白质复合物。哮喘的生物标志物。与人类 PRMT5（蛋白质精氨酸甲基转移酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; positive regulation of oligodendrocyte differentiation; and regulation of ERK1 and ERK2 cascade. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]

Prmt5 基因产物(1)

mRNA Protein Name
NM_001108867.2 NP_001102337.2 protein arginine N-methyltransferase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15837430 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in liver regeneration IEP
IEP: 通过表达模式推断
15837430 RGD
involved in negative regulation of cell differentiation IMP
IMP: 通过突变表型推断
21917714 RGD
involved in negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: 通过突变表型推断
22041901 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
22041901 RGD
involved in protein methylation IMP
IMP: 通过突变表型推断
21917714 RGD
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
21917714 RGD
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
22041901 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
12101096 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prmt5 蛋白结构

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 289)

PRMT5

PRMT5: pfam05185 (294 - 463)

PRMT5_C

PRMT5_C: pfam17286 (467 - 634)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 637 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 5

HMT1 hnRNP methyltransferase-like 5

SKB1 homolog

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-101563 GSK3326595 Inhibitor 99.97% Phase 2
HY-139611 MRTX-1719 Inhibitor 99.40% Phase 2
HY-148419 TNG908 Inhibitor 98.89% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.69% Phase 1
Pre-clinical Phase
生物活性分子 (30)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12727 EPZ015666 Inhibitor 99.83% 否
HY-100235 GSK591 Inhibitor 99.91% 否
HY-107777 LLY-283 Inhibitor 99.22% 否
HY-138684 MRTX9768 Inhibitor 99.60% 否
HY-148674 PRMT5-IN-25 Inhibitor 99.94% 否
HY-132309 BRD0639 Inhibitor 98.04% 否
HY-124131 DS-437 Inhibitor 98.00% 否
HY-100025A HLCL-61 hydrochloride Inhibitor 99.84% 否
HY-139611C MRTX-1719 hydrochloride Inhibitor 99.22% 否
HY-120137 CMP-5 Inhibitor 99.02% 否
HY-Q36691 PRMT5-IN-30 Inhibitor 99.17% 否
HY-126256 PRMT5-IN-1 Inhibitor / 否
HY-134883 PRMT5-IN-4 Inhibitor ≥99.0% 否
HY-141876 PRMT5-IN-14 Inhibitor / 否
HY-139611B (S)-MRTX-1719 Inhibitor 97.07% 否
HY-162230 PRMT5-IN-33 Inhibitor / 否
HY-146810 PRMT4-IN-1 Inhibitor / 否
HY-P3822 PRMT5-IN-23 Inhibitor / 否
HY-163799 PRMT5-MTA-IN-1 Inhibitor / 否
HY-149005 PRMT5-IN-19 Inhibitor / 否
HY-168263 PRMT5-IN-45 Inhibitor / 否
HY-153421 PRMT5-IN-28 Inhibitor / 否
HY-163592 PRMT5-IN-43 Inhibitor / 否
HY-161334 CARM1-IN-4 Inhibitor / 否
HY-163587 PRMT5-IN-39-d3 Inhibitor / 否
HY-158143 PRMT5-IN-34 Inhibitor / 否
HY-163591 PRMT5-IN-36-d3 Inhibitor / 否
HY-150081 PRMT5-IN-21 Inhibitor / 否
HY-163593 PRMT5-IN-44 Inhibitor / 否
HY-132937 PRMT5-IN-9 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prmt5 NCBI NCBI:10419
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