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  3. Tlr3 - toll-like receptor 3 Gene

Tlr3 - toll-like receptor 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Toll样受体 3

种属: Rattus norvegicus

基因 ID: 364594 | 基因类型: protein coding

关于 Tlr3

Primary_assembly 16: 46,822,039-46,836,545 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 156 orthologues, 26 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 17.4), Kidney (RPKM 158.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动双链 RNA 结合活性。参与多个过程，包括细胞对细胞因子刺激的反应；对外源性 dsRNA 的细胞反应；和小胶质细胞活化。位于细胞表面。用于研究哮喘。结肠炎的生物标志物；胰腺炎;围产期坏死性小肠结肠炎；周围神经系统疾病；和先兆子痫。该基因的人类直系同源基因与多种疾病有关，包括乙型肝炎；丙型肝炎;人类免疫缺陷病毒传染病；肝硬化;和 1 型糖尿病。与人类 TLR3（toll 样受体 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Located in cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlr3 基因产物(1)

mRNA Protein Name
NM_198791.2 NP_942086.2 toll-like receptor 3 precursor

Tlr3 蛋白结构

LRR_RI

LRR_RI: sd00033 (36 - 52)

LRR_RI

LRR_RI: sd00033 (53 - 76)

PLN00113

PLN00113: cl33413 (65 - 645)

LRR_RI

LRR_RI: sd00033 (77 - 100)

LRR_RI

LRR_RI: sd00033 (101 - 124)

LRR_RI

LRR_RI: sd00033 (125 - 148)

LRR_RI

LRR_RI: sd00033 (149 - 198)

LRR_RI

LRR_RI: sd00033 (199 - 249)

LRR_RI

LRR_RI: sd00033 (250 - 275)

LRR_RI

LRR_RI: sd00033 (276 - 299)

LRR_RI

LRR_RI: sd00033 (300 - 321)

LRR_RI

LRR_RI: sd00033 (324 - 380)

LRR_RI

LRR_RI: sd00033 (381 - 406)

LRR_RI

LRR_RI: sd00033 (409 - 432)

LRR_RI

LRR_RI: sd00033 (433 - 457)

LRR_RI

LRR_RI: sd00033 (458 - 481)

LRR_RI

LRR_RI: sd00033 (482 - 507)

LRR_RI

LRR_RI: sd00033 (508 - 531)

LRR_RI

LRR_RI: sd00033 (532 - 563)

LRR_RI

LRR_RI: sd00033 (564 - 585)

LRR_RI

LRR_RI: sd00033 (588 - 611)

LRR_RI

LRR_RI: sd00033 (612 - 630)

LRRCT

LRRCT: smart00082 (645 - 697)

Tlr3_TMD

Tlr3_TMD: pfam17968 (698 - 730)

TIR

TIR: smart00255 (755 - 900)

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  • 905 a.a.
蛋白主名 其他名称

toll-like receptor 3

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108473 CU-CPT 4a Inhibitor 99.34% 否
HY-135748 Polyinosinic-polycytidylic acid sodium Agonist 99.4% 否
HY-101929 CU-CPT17e Agonist 99.00% 否
HY-18325 AN-3485 Inhibitor 95.63% 否
HY-134958 Polyinosinic-polycytidylic acid potassium Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tlr3 NCBI NCBI:7098
Macaca fascicularis Tlr3 NCBI NCBI:102138517
Mus musculus Tlr3 NCBI NCBI:142980
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