2. Gene
  3. Ntsr1 - neurotensin receptor 1 Gene

Ntsr1 - neurotensin receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：神经降压素受体 1

种属: Rattus norvegicus

同用名: Ntsr

基因 ID: 366274 | 基因类型: protein coding

关于 Ntsr1

Primary_assembly 3: 167,606,215-167,656,377 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 213 orthologues, 14 paralogues and is associated with 10 phenotypes. Biased expression in Brain (RPKM 6.6), Muscle (RPKM 3.2) and 7 other tissues.

功能概要

实现相同的蛋白质结合活性和蛋白质 N 末端结合活性。参与多个过程，包括氨基酸跨质膜输入；离子传输的调节；和调节神经系统过程。位于多个细胞成分中，包括树突；核周;和对称突触。该基因的人类直系同源物与精神分裂症有关。与人类 NTSR1（神经降压素受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including amino acid import across plasma membrane; regulation of ion transport; and regulation of nervous system process. Located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human NTSR1 (Neurotensin Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntsr1 基因产物(1)

mRNA Protein Name
NM_001108967.2 NP_001102437.1 neurotensin receptor type 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17188644 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16708210 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17188644 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-aspartate import across plasma membrane IDA
IDA: 通过直接分析推断
12123836 RGD
involved in L-glutamate import across plasma membrane IDA
IDA: 通过直接分析推断
12123836 RGD
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
15733655 RGD
involved in inositol phosphate catabolic process IMP
IMP: 通过突变表型推断
15707678 RGD
involved in learning IMP
IMP: 通过突变表型推断
21946307 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
12084713 RGD
involved in negative regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
22211865 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
18063561 RGD
involved in positive regulation of arachidonate secretion IMP
IMP: 通过突变表型推断
11852105 RGD
involved in positive regulation of cation channel activity IMP
IMP: 通过突变表型推断
19359367 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
15716398 RGD
involved in positive regulation of glutamate secretion IMP
IMP: 通过突变表型推断
18063561 RGD
involved in positive regulation of inhibitory postsynaptic potential IMP
IMP: 通过突变表型推断
15664687 RGD
involved in positive regulation of inositol phosphate biosynthetic process IMP
IMP: 通过突变表型推断
11861328 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
10799761 RGD
involved in regulation of membrane depolarization IMP
IMP: 通过突变表型推断
15120846 RGD
involved in regulation of respiratory gaseous exchange IMP
IMP: 通过突变表型推断
22211865 RGD
involved in response to lipid IDA
IDA: 通过直接分析推断
22306739 RGD
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
7620825 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8876464 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
8876464 RGD
located in cell surface IDA
IDA: 通过直接分析推断
17188644 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
9763490 RGD
located in dendrite IDA
IDA: 通过直接分析推断
10818259 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
9763490 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
9763490 RGD
located in neuron spine IDA
IDA: 通过直接分析推断
10818259 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
9763490 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
10818259 RGD
located in symmetric synapse IDA
IDA: 通过直接分析推断
10818259 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
10818259 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ntsr1 蛋白结构

7tmA_NTSR1

7tmA_NTSR1: cd15355 (64 - 91)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (64 - 379)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (101 - 127)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (141 - 171)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (183 - 205)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (233 - 262)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (300 - 330)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (347 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
蛋白主名 其他名称

neurotensin receptor type 1

NT-R-1

NTR1

NTRH

high-affinity levocabastine-insensitive neurotensin receptor

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125880 SBI-553 Modulator 99.73% 否
HY-RS09638 NTSR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-P10698 VH-N412 / 否
HY-RS09639 Ntsr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09640 Ntsr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ntsr1 NCBI NCBI:4923
Macaca fascicularis Ntsr1 NCBI NCBI:102115340
Mus musculus Ntsr1 NCBI NCBI:18216
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z