NTSR1 - neurotensin receptor 1 Gene

中文名称：神经降压素受体 1

种属: Homo sapiens

同用名: NTR

基因 ID: 4923 | 基因类型: protein coding

关于 NTSR1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,708,836-62,762,771 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 15 paralogues. Low expression observed in reference dataset.

功能概要

神经降压素受体 1 属于 G 蛋白偶联受体的大超家族。 NTSR1 介导神经降压素的多种功能，例如低血压、高血糖、低体温、抗伤害作用以及调节肠蠕动和分泌。[RefSeq 提供，2008 年 7 月]

Neurotensin Receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

NTSR1 基因产物(1)

mRNA	Protein	Name
NM_002531.3	NP_002522.2	neurotensin receptor type 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled neurotensin receptor activity	IDA IDA: 通过直接分析推断	21725197	GOA
enables G protein-coupled neurotensin receptor activity	IMP IMP: 通过突变表型推断	8381365	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17620610	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17620610	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	21725197	GOA
involved in neuropeptide signaling pathway	IDA IDA: 通过直接分析推断	21725197	GOA
involved in neuropeptide signaling pathway	IGI IGI: 通过遗传相互作用推断	21806946	GOA
acts upstream of positive regulation of gene expression	IGI IGI: 通过遗传相互作用推断	21806946	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane raft	IDA IDA: 通过直接分析推断	21725197	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	8381365	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NTSR1 蛋白结构

7tm_1

0
100
200
300
418 a.a.

蛋白主名

其他名称

neurotensin receptor type 1

NT-R-1	NTR1
NTRH	high-affinity levocabastine-insensitive neurotensin receptor
neurotensin receptor 1 (high affinity)

NTSR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NTSR1	P30989	NTS	Homo sapiens	P30990	Light Scattering	17620610
种属内	NTSR1	P30989	NTSR1	Homo sapiens	P30989	Light Scattering	17620610
种属内	NTSR1	P30989	NTSR1	Homo sapiens	P30989	GMS	17620610
种属内	NTSR1	P30989	NTS	Homo sapiens	P30990	GMS	17620610
种属内	NTSR1	P30989	P30990-PRO_0000019524	Homo sapiens	P30990-PRO_0000019524	SPA	23597562

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Trigeminal Nerve Neoplasm

Neoplasm Of Trigeminal Nerve

Tumor Of Trigeminal Nerve

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Brain Stem Medulloblastoma

Jugular Foramen Meningioma

Meningioma Of The Jugular Foramen

Acute Flaccid Myelitis

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Schwannoma Of Twelfth Cranial Nerve

Hypoglossal Schwannoma

Schwannoma Of The Twelfth Cranial Nerve

Suprasellar Meningioma

Hypoglossal Nerve Disease

Hypoglossal Nerve Diseases	Disorder Of 12th Nerve
Disorder Of Hypoglossal [12th] Nerve	Disorder Of Hypoglossal Nerve
Disorder Of Xii Nerve	Disorders Of The Twelfth Cranial Nerve
Disorders Of 12th Cranial Nerve

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Neurilemmoma Of The Fifth Cranial Nerve

Trigeminal Schwannoma

Trigeminal Neurilemmoma

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-125880	SBI-553	Modulator	99.73%	否
HY-RS09638	NTSR1 Human Pre-designed siRNA Set A		/	否
HY-164795	SBI-810	Modulator	/	否
HY-164795A	SBI-810 hydrochloride	Modulator	99.11%	否
HY-P10698	VH-N412		/	否
HY-RS09639	Ntsr1 Mouse Pre-designed siRNA Set A		/	否
HY-RS09640	Ntsr1 Rat Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NTSR1	RGD	RGD:1306076
Canis familiaris	NTSR1	VGNC	VGNC:44014
Bos taurus	NTSR1	VGNC	VGNC:32312
Felis catus	NTSR1	VGNC	VGNC:68582
Mus musculus	NTSR1	MGD	MGI:97386
Macaca mulatta	NTSR1	VGNC	VGNC:75544
Macaca fascicularis	NTSR1	NCBI	NCBI:102115340
Others	NTSR1	NCBI

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