ITGB7 - integrin subunit beta 7 Gene

中文名称：整合素 7 亚基

种属: Homo sapiens

关于 ITGB7

功能概要

该基因编码的蛋白质是整合素超家族的成员。该家族的成员是粘附受体，在从细胞外基质到细胞的信号传递中发挥作用。整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。编码的蛋白质与 alpha4 链或 alphaE 链形成二聚体，并在白细胞粘附中发挥作用。与 alpha4 的二聚化形成了一个归巢受体，用于将淋巴细胞迁移到肠粘膜和淋巴结。与 alphaE 的二聚化允许与配体上皮钙粘蛋白 (一种钙依赖性粘附分子) 结合。交替剪接导致多个转录本变体。已经描述了该基因的其他可变剪接转录变体，但它们的全长性质尚不清楚。[RefSeq 提供，2013 年 9 月]

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]