KCNA3 - potassium voltage-gated channel subfamily A member 3 Gene

中文名称：钾电压门控通道亚家族 A 成员 3

种属: Homo sapiens

同用名: MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII

关于 KCNA3

功能概要

从功能和结构的角度来看，钾通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。四种序列相关的钾通道基因——shaker、shaw、shab 和 shal——已在果蝇中被鉴定出来，并且每一种都被证明具有人类同系物。该基因编码钾通道、电压门控、摇床相关亚家族的成员。该成员包含六个跨膜结构域，在第四部分中具有振动型重复序列。它属于延迟整流器类，其成员允许神经细胞在动作电位后有效地复极化。它在 T 细胞增殖和激活中起重要作用。该基因似乎是无内含子的，它与 1 号染色体上的 KCNA2 和 KCNA10 基因聚集在一起。[RefSeq 提供，2008 年 7 月]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]