2. Gene
  3. NRROS - negative regulator of reactive oxygen species Gene

NRROS - negative regulator of reactive oxygen species Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：活性氧的负调节因子

种属: Homo sapiens

同用名: GARPL1; LRRC33; SENEBAC; UNQ3030; ELLP3030

基因 ID: 375387 | 基因类型: protein coding

关于 NRROS

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,639,694-196,662,004 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 8.2) and 22 other tissues.

功能概要

启用转化生长因子 β 结合活性。预计参与多个过程，包括小胶质细胞发育；在细胞外基质中隔离 TGFbeta；和转化生长因子 beta1 激活。位于细胞表面。 [由基因组资源联盟提供，2022 年 4 月]

Enables transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NRROS 基因产物(1)

mRNA Protein Name
NM_198565.3 NP_940967.1 transforming growth factor beta activator LRRC33 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
29909984 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
29909984 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NRROS 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (134 - 156)

LRR_8

LRR_8: Leucine rich repeat (157 - 217)

LRR_8

LRR_8: Leucine rich repeat (330 - 388)

LRR_6

LRR_6: Leucine Rich repeat (426 - 439)

(463 - 478)

(536 - 552)

LRR_1

LRR_1: Leucine Rich Repeat (560 - 575)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
蛋白主名 其他名称

transforming growth factor beta activator LRRC33

glycoprotein A repetitions predominant like 1

重组 NRROS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72063 NRROS Protein, Human (Baculovirus, His-Myc) Q86YC3 (W19-L650) ≥95%

关联疾病

疾病名称 别名
Seizures, Early-Onset, With Neurodegeneration And Brain Calcifications

Seizures, Early-Onset, With Neurodegeneration And Brain Calcification

SENEBAC
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome

Chromosome 3q29 Microdeletion Syndrome

3q29 Microdeletion Syndrome

3q Subtelomere Deletion Syndrome

3q29 Recurrent Deletion

3qter Deletion

3q29 Deletion Syndrome

Monosomy 3q29

Microdeletion 3q29 Syndrome

Del(3)(Q29)

Monosomy 3qter

3q29 Deletion

Del3q29
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09581 NRROS Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NRROS VGNC VGNC:63883
Macaca mulatta NRROS VGNC VGNC:75456
Rattus norvegicus NRROS RGD RGD:1310771
Bos taurus NRROS VGNC VGNC:53592
Mus musculus NRROS MGD MGI:2445095
Others NRROS NCBI
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