2. Gene
  3. KLK2 - kallikrein related peptidase 2 Gene

KLK2 - kallikrein related peptidase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激肽释放酶相关肽酶 2

种属: Homo sapiens

同用名: hK2; hGK-1; KLK2A2

基因 ID: 3817 | 基因类型: protein coding

关于 KLK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,873,439-50,880,567 (from NCBI)

This gene has 23 transcripts (splice variants), 144 orthologues, 12 paralogues and is associated with 48 phenotypes. Restricted expression toward prostate (RPKM 1047.4).

功能概要

该基因编码颗粒状激肽释放酶蛋白家族的成员。激肽释放酶是聚集在 19 号染色体上的丝氨酸蛋白酶的一个亚组。该家族的成员参与多种生物学功能。该基因编码的蛋白质是一种高活性的胰蛋白酶样丝氨酸蛋白酶，可选择性地切割精氨酸残基。这种蛋白质主要在前列腺组织中表达，并负责将前前列腺特异性抗原切割成其酶促活性形式。该基因在前列腺肿瘤细胞中高度表达，可能是前列腺癌风险的预后指标。交替剪接导致编码和非编码转录物变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a member of the grandular Kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine Protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate Cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

KLK2 基因产物(3)

mRNA Protein Name
NM_001002231.3 NP_001002231.1 kallikrein-2 isoform 2 preproprotein
NM_001256080.2 NP_001243009.1 kallikrein-2 isoform 3
NM_005551.5 NP_005542.1 kallikrein-2 isoform 1 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
9042371 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLK2 蛋白结构

Trypsin

Trypsin: Trypsin (25 - 253)

  • 0
  • 100
  • 200
  • 261 a.a.
蛋白主名 其他名称

kallikrein-2

glandular kallikrein 2

重组 KLK2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70317 Kallikrein-2 Protein, Human (HEK293, His) P20151-1 (P19-P261) ≥95%

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Prostate Disease

Prostatic Diseases

Prostate Diseases
Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia

BPH

Prostatic Hyperplasia
Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia
Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07380 KLK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Others KLK2 NCBI
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