2. Gene
  3. KLRC2 - killer cell lectin like receptor C2 Gene

KLRC2 - killer cell lectin like receptor C2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：杀伤细胞凝集素样受体 C2

种属: Homo sapiens

同用名: NKG2C; CD159c; NKG2-C

基因 ID: 3822 | 基因类型: protein coding

关于 KLRC2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,430,599-10,436,010 (from NCBI)

This gene has 5 transcripts (splice variants), 460 orthologues and 23 paralogues. Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues.

功能概要

自然杀伤 (NK) 细胞是淋巴细胞，无需预先激活即可介导某些肿瘤细胞和病毒感染细胞的裂解。它们还可以调节特定的体液免疫和细胞介导的免疫。 NK 细胞优先表达几种钙依赖性 (C 型) 凝集素，这些凝集素与 NK 细胞功能的调节有关。该组命名为 KLRC (NKG2) ，主要在自然杀伤 (NK) 细胞中表达，并编码以 II 型膜方向 (细胞外 C 末端) 和 C 型凝集素结构域为特征的跨膜蛋白家族。 KLRC (NKG2) 基因家族位于 NK 复合体中，该区域包含优先在 NK 细胞上表达的几个 C 型凝集素基因。已经描述了 KLRC2 替代剪接变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

KLRC2 基因产物(1)

mRNA Protein Name
NM_002260.4 NP_002251.2 NKG2-C type II integral membrane protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class I protein complex binding IPI
IPI: 通过物理相互作用推断
18448674 GOA
enables activating MHC class Ib receptor activity IDA
IDA: 通过直接分析推断
9754572 GOA
enables protein antigen binding IDA
IDA: 通过直接分析推断
18448674 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9655483 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in natural killer cell mediated immunity IDA
IDA: 通过直接分析推断
18448674 GOA
involved in positive regulation of natural killer cell degranulation IDA
IDA: 通过直接分析推断
21825173 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
9754572 GOA
involved in stimulatory C-type lectin receptor signaling pathway IDA
IDA: 通过直接分析推断
9655483 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
9655483 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
18448674 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLRC2 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (135 - 228)

  • 0
  • 100
  • 200
  • 231 a.a.
蛋白主名 其他名称

NKG2-C type II integral membrane protein

CD159 antigen-like family member C

重组 KLRC2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77807 NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26717 (E98-L231)&Q13241 (S34-I179) ≥95%
HY-P78006 NKG2C/CD159c Protein, Human (HEK293, His-Avi) P26717 (E98-L231) ≥95%
HY-P700799 NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi) P26717 (E98-L231) ≥95%
HY-P700800 NKG2C/CD159c Protein, Human (HEK293, hFc) P26717 (E98-L231) ≥95%

关联疾病

疾病名称 别名
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Nk Cell Deficiency
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07392 KLRC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KLRC2 MGD MGI:1336162
Rattus norvegicus KLRC2 RGD RGD:2977
Macaca fascicularis KLRC2 NCBI
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