RHOB - ras homolog family member B Gene

中文名称：ras 同系物家族成员 B

种属: Homo sapiens

同用名: ARH6; ARHB; RHOH6; MST081; MSTP081

基因 ID: 388 | 基因类型: protein coding

关于 RHOB

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,447,074-20,449,440 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 22 paralogues.

功能概要

预计启用 GTP 绑定活动； GTP 酶活性；和蛋白激酶结合活性。参与多个过程，包括细胞对过氧化氢的反应；细胞对电离辐射的反应；和细胞迁移的调节。位于卵裂沟和核内体膜。乳腺癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

RHOB 基因产物(1)

mRNA	Protein	Name
NM_004040.4	NP_004031.1	rho-related GTP-binding protein RhoB

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19637314	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to hydrogen peroxide	IDA IDA: 通过直接分析推断	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: 通过直接分析推断	21373644	GOA
involved in endosome to lysosome transport	IDA IDA: 通过直接分析推断	10508588	GOA
involved in endothelial tube morphogenesis	IMP IMP: 通过突变表型推断	21347332	GOA
involved in mitotic cytokinesis	IMP IMP: 通过突变表型推断	16236794	GOA
involved in negative regulation of cell migration	IDA IDA: 通过直接分析推断	20460403	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	21373644	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	21347332	GOA
involved in regulation of cell migration	IGI IGI: 通过遗传相互作用推断	20460403	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cleavage furrow	IDA IDA: 通过直接分析推断	16236794	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	15226397	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15226397	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHOB 蛋白结构

Ras

0
100
196 a.a.

蛋白主名

其他名称

rho-related GTP-binding protein RhoB

Aplysia RAS-related homolog 6

RHOB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RHOB	P62745	TNFAIP1	Homo sapiens	Q13829	Y2H	19637314
种属内	RHOB	P62745	SMURF1	Homo sapiens	Q9HCE7-2	Pull Down	25249323

种属间: 跨种属相互作用 种属内: 同种属相互作用

RHOB 抗体

目录号	产品名	应用	反应物种
HY-P80882	RhoA/B/C Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Tangier Disease

Analphalipoproteinemia	High Density Lipoprotein Deficiency, Tangier Type
TGD	High Density Lipoprotein Deficiency, Type 1
Hdldt1	Familial High Density Lipoprotein Deficiency
A-Alphalipoprotein Neuropathy	Alpha High Density Lipoprotein Deficiency Disease
Cholesterol Thesaurismosis	Familial High Density Lipoprotein Deficiency Disease
Hdl Lipoprotein Deficiency Disease	Tangier Disease Neuropathy
Familial Alpha-Lipoprotein Deficiency	Familial High-Density Lipoprotein Deficiency 1
Primary Hypoalphalipoproteinemia 1	Analphalipo-Proteinemia
Familial Hypoalphalipo-Proteinemia	Familial Hypoalphalipoproteinemia
Lipoprotein Deficiency Disease, Hdl, Familial	Tangier Hereditary Neuropathy
Atp-Binding Cassette Transporter A1 Deficiency	Hdld1
High Density Lipoprotein Deficiency 1	Tangier Disease, Variant
Hypoalphalipoproteinemia, Familial	Familial Hdl Deficiency

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-28099	VEC6		/	否
HY-RS11946	RHOB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RHOB	VGNC	VGNC:45555
Bos taurus	RHOB	VGNC	VGNC:33944
Mus musculus	RHOB	MGD	MGI:107949
Felis catus	RHOB	VGNC	VGNC:68084
Rattus norvegicus	RHOB	RGD	RGD:621309

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RHOB - ras homolog family member B Gene

关于 RHOB

功能概要

RHOB 基因产物(1)

RHOB 蛋白结构

RHOB 蛋白互作信息

RHOB 抗体

关联疾病

直系同源

热门区域

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RHOB - ras homolog family member B Gene

关于 RHOB

功能概要

RHOB 基因产物(1)

RHOB 蛋白结构

RHOB 蛋白互作信息

RHOB 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z