1. Gene
  2. RHOB - ras homolog family member B Gene

RHOB - ras homolog family member B Gene

中文名称:ras 同系物家族成员 B

种属: Homo sapiens

同用名: ARH6; ARHB; RHOH6; MST081; MSTP081

基因 ID: 388 | 基因类型: protein coding

关于 RHOB

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,447,074-20,449,440 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 22 paralogues.

功能概要

预计启用 GTP 绑定活动; GTP 酶活性;和蛋白激酶结合活性。参与多个过程,包括细胞对过氧化氢的反应;细胞对电离辐射的反应;和细胞迁移的调节。位于卵裂沟和核内体膜。乳腺癌的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

RHOB 基因产物(1)

mRNA Protein Name
NM_004040.4 NP_004031.1 rho-related GTP-binding protein RhoB
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19637314 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
21373644 GOA
involved in cellular response to ionizing radiation IDA
IDA: 通过直接分析推断
21373644 GOA
involved in endosome to lysosome transport IDA
IDA: 通过直接分析推断
10508588 GOA
involved in endothelial tube morphogenesis IMP
IMP: 通过突变表型推断
21347332 GOA
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
16236794 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
20460403 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
21373644 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
21347332 GOA
involved in regulation of cell migration IGI
IGI: 通过遗传相互作用推断
20460403 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
16236794 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
15226397 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15226397 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RHOB 蛋白结构

Ras

Ras: Ras family (7 - 179)

  • 0
  • 100
  • 196 a.a.
蛋白主名 其他名称

rho-related GTP-binding protein RhoB

Aplysia RAS-related homolog 6

RHOB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RHOB P62745 TNFAIP1 Homo sapiens Q13829
Y2H
19637314
种属内
RHOB P62745 SMURF1 Homo sapiens Q9HCE7-2 25249323
种属间: 跨种属相互作用 种属内: 同种属相互作用

RHOB 抗体

目录号 产品名 应用 反应物种
HY-P80882 RhoA/B/C Antibody WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Tangier Disease

Analphalipoproteinemia

High Density Lipoprotein Deficiency, Tangier Type

TGD

High Density Lipoprotein Deficiency, Type 1

Hdldt1

Familial High Density Lipoprotein Deficiency

A-Alphalipoprotein Neuropathy

Alpha High Density Lipoprotein Deficiency Disease

Cholesterol Thesaurismosis

Familial High Density Lipoprotein Deficiency Disease

Hdl Lipoprotein Deficiency Disease

Tangier Disease Neuropathy

Familial Alpha-Lipoprotein Deficiency

Familial High-Density Lipoprotein Deficiency 1

Primary Hypoalphalipoproteinemia 1

Analphalipo-Proteinemia

Familial Hypoalphalipo-Proteinemia

Familial Hypoalphalipoproteinemia

Lipoprotein Deficiency Disease, Hdl, Familial

Tangier Hereditary Neuropathy

Atp-Binding Cassette Transporter A1 Deficiency

Hdld1

High Density Lipoprotein Deficiency 1

Tangier Disease, Variant

Hypoalphalipoproteinemia, Familial

Familial Hdl Deficiency

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RHOB VGNC VGNC:45555
Bos taurus RHOB VGNC VGNC:33944
Mus musculus RHOB MGD MGI:107949
Felis catus RHOB VGNC VGNC:68084
Rattus norvegicus RHOB RGD RGD:621309