1. Gene
  2. SCIMP - SLP adaptor and CSK interacting membrane protein Gene

SCIMP - SLP adaptor and CSK interacting membrane protein Gene

中文名称:SLP 适配器和 CSK 相互作用膜蛋白

种属: Homo sapiens

同用名: UNQ5783; C17orf87

基因 ID: 388325 | 基因类型: protein coding

关于 SCIMP

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,208,920-5,234,860 (from NCBI)

This gene has 4 transcripts (splice variants), 88 orthologues and 2 paralogues. Biased expression in spleen (RPKM 11.9), lymph node (RPKM 9.3) and 13 other tissues.

功能概要

该基因编码一种跨膜衔接蛋白,该蛋白在抗原呈递细胞中表达并位于免疫突触中。编码的蛋白质参与主要组织相容性复合物 II 类信号转导和免疫突触形成。已发现该基因的可变剪接转录物变体。[RefSeq 提供,2012 年 12 月]

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

SCIMP 基因产物(3)

mRNA Protein Name
NM_001271842.1 NP_001258771.1 SLP adapter and CSK-interacting membrane protein isoform 2
NM_001319190.2 NP_001306119.1 SLP adapter and CSK-interacting membrane protein isoform 3
NM_207103.3 NP_996986.1 SLP adapter and CSK-interacting membrane protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21930792 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
21930792 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in immunological synapse IDA
IDA: 通过直接分析推断
21930792 GOA
located in leading edge membrane IDA
IDA: 通过直接分析推断
21930792 GOA
located in membrane IDA
IDA: 通过直接分析推断
21930792 GOA
located in tetraspanin-enriched microdomain IDA
IDA: 通过直接分析推断
21930792 GOA
located in uropod membrane IDA
IDA: 通过直接分析推断
21930792 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SCIMP 蛋白结构

SCIMP

SCIMP: SCIMP protein (12 - 143)

  • 0
  • 100
  • 145 a.a.
蛋白主名 其他名称

SLP adapter and CSK-interacting membrane protein

DTFT5783

SCIMP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SCIMP Q6UWF3 CSK Homo sapiens P41240 21930792
种属内
SCIMP Q6UWF3 CCDC81 Homo sapiens Q6ZN84 21930792
种属内
SCIMP Q6UWF3 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
SCIMP Q6UWF3 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
SCIMP Q6UWF3 LYN Homo sapiens P07948 21930792
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus SCIMP VGNC VGNC:99447
Canis familiaris SCIMP VGNC VGNC:59032
Mus musculus SCIMP MGD MGI:3610314
Rattus norvegicus SCIMP RGD RGD:1593299
Bos taurus SCIMP VGNC VGNC:34338
Macaca mulatta SCIMP VGNC VGNC:77146