1. Gene
  2. LDHC - lactate dehydrogenase C Gene

LDHC - lactate dehydrogenase C Gene

中文名称:乳酸脱氢酶 C

种属: Homo sapiens

同用名: CT32; LDH3; LDHX

基因 ID: 3948 | 基因类型: protein coding

关于 LDHC

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,412,318-18,452,063 (from NCBI)

This gene has 10 transcripts (splice variants), 98 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 186.5).

功能概要

乳酸脱氢酶 C 在无氧糖酵解的最后一步催化 L-乳酸和 NAD 转化为丙酮酸和 NADH。 LDHC 是睾丸特异性的,属于乳酸脱氢酶家族。已检测到两种转录本变体,它们在 5' 非翻译区有所不同。[RefSeq 提供,2008 年 7 月]

Lactate Dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the Lactate Dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

LDHC 基因产物(2)

mRNA Protein Name
NM_002301.5 NP_002292.1 L-lactate dehydrogenase C chain
NM_017448.5 NP_059144.1 L-lactate dehydrogenase C chain
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LDHC 蛋白结构

Ldh_1_N

Ldh_1_N: lactate/malate dehydrogenase, NAD binding domain (21 - 160)

Ldh_1_C

Ldh_1_C: lactate/malate dehydrogenase, alpha/beta C-terminal domain (164 - 326)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

L-lactate dehydrogenase C chain

LDH testis subunit

LDHC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LDHC P07864 LDHB Homo sapiens P07195
Anti Tag CoIP
33961781
种属内
LDHC P07864 LDHA Homo sapiens P00338
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

LDHC 抗体

目录号 产品名 应用 反应物种
HY-P80739 Lactate Dehydrogenase C Antibody WB Human

关联疾病

疾病名称 别名
Varicocele

Scrotal Varices

Varicoceles

Varicocele Of Scrotum

Scrotal Varicocele

Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

Nuclear Senile Cataract

Senile Nuclear Cataract

Senile Nuclear Sclerosis

Phototoxic Dermatitis

Dermatitis, Phototoxic

Photosensitisation Reaction

Photosensitive Dermatitis

Photosensitiveness

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LDHC RGD RGD:69366
Bos taurus LDHC VGNC VGNC:56270
Mus musculus LDHC MGD MGI:96764
Felis catus LDHC VGNC VGNC:82036
Macaca mulatta LDHC VGNC VGNC:74247
Canis familiaris LDHC VGNC VGNC:52264
Others LDHC NCBI