2. Gene
  3. LGALS2 - galectin 2 Gene

LGALS2 - galectin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：半乳糖凝集素 2

种属: Homo sapiens

同用名: HL14

基因 ID: 3957 | 基因类型: protein coding

关于 LGALS2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,570,248-37,580,087 (from NCBI)

This gene has 2 transcripts (splice variants), 325 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in gall bladder (RPKM 133.8), small intestine (RPKM 81.3) and 7 other tissues.

功能概要

该基因编码的蛋白质是一种可溶性β-半乳糖苷结合凝集素。编码的蛋白质被发现为同型二聚体，可以与淋巴毒素-α 结合。该基因内含子中的单核苷酸多态性可以改变蛋白质的转录水平，从而增加心肌梗塞的风险。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

LGALS2 基因产物(1)

mRNA Protein Name
NM_006498.3 NP_006489.1 galectin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell homeostasis IDA
IDA: 通过直接分析推断
15356130 GOA
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
15356130 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
15356130 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of galectin complex IPI
IPI: 通过物理相互作用推断
8262940 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGALS2 蛋白结构

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (7 - 128)

  • 0
  • 100
  • 132 a.a.
蛋白主名 其他名称

galectin-2

S-Lac lectin 2

LGALS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
种属内
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Array
25416956
种属内
LGALS2 P05162 SDCBP Homo sapiens O00560
Y2H Array
32296183
种属内
LGALS2 P05162 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
种属内
LGALS2 P05162 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LGALS2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700078AF Animal-Free Galectin-2/LGALS2 Protein, Human (His) P05162 (T2-E132) ≥95%
HY-P700301 Galectin-2/LGALS2 Protein, Human (GST) P05162 (M1-E132) ≥95%

关联疾病

疾病名称 别名
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Blackwater Fever

Black Water Fever

Hemoglobinuric, Malaria

Malarial Hemoglobinuria
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07603 LGALS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LGALS2 VGNC VGNC:74254
Mus musculus LGALS2 MGD MGI:895068
Felis catus LGALS2 VGNC VGNC:68039
Canis familiaris LGALS2 VGNC VGNC:42647
Rattus norvegicus LGALS2 RGD RGD:621269
Bos taurus LGALS2 VGNC VGNC:50210
Macaca fascicularis LGALS2 NCBI NCBI:102130960
Others LGALS2 NCBI
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