2. Gene
  3. LGALS3BP - galectin 3 binding protein Gene

LGALS3BP - galectin 3 binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：半乳糖凝集素 3 结合蛋白

种属: Homo sapiens

同用名: 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B

基因 ID: 3959 | 基因类型: protein coding

关于 LGALS3BP

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,971,255-78,979,923 (from NCBI)

This gene has 19 transcripts (splice variants), 254 orthologues and 15 paralogues. Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues.

功能概要

半乳糖凝集素是β-半乳糖苷结合蛋白家族，参与调节细胞-细胞和细胞-基质相互作用。已发现 LGALS3BP 在癌症患者和感染人类免疫缺陷病毒 (HIV) 的患者的血清中升高。它似乎涉及与自然杀伤 (NK) 和淋巴因子激活的杀伤 (LAK) 细胞细胞毒性相关的免疫反应。使用荧光原位杂交，全长 90K cDNA 已定位于染色体 17q25。天然蛋白质特异性结合称为 Mac-2 的人类巨噬细胞相关凝集素，还结合半乳糖凝集素 1。[RefSeq 提供，2008 年 7 月]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with Cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds Galectin 1. [provided by RefSeq, Jul 2008]

LGALS3BP 基因产物(1)

mRNA Protein Name
NM_005567.4 NP_005558.1 galectin-3-binding protein precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26618866 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
25645918 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGALS3BP 蛋白结构

SRCR

SRCR: Scavenger receptor cysteine-rich domain (28 - 124)

BACK

BACK: BTB And C-terminal Kelch (261 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
蛋白主名 其他名称

galectin-3-binding protein

L3 antigen

关联疾病

疾病名称 别名
Varicose Veins

Varices

Varix

Venous Ectasia

Venous Varices

Varicosity
Strongyloidiasis

Disseminated Strongyloidiasis

Anguilluliasis

Anguillulosis

Infection By Strongyloides

Threadworm Infection

Enterobiasis
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Esophageal Varix

Esophageal Varices

Bleeding Esophageal Varices

Bleeding Oesophageal Varices

Esophageal Varices In Disease Classified Elsewhere, With Bleeding

Esophageal Varices With Bleeding

Esophageal Varices With Bleeding In Disease Ec

Esophageal Varices Without Bleeding

Esophageal Varices Without Mention Of Bleeding
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07605 LGALS3BP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LGALS3BP MGD MGI:99554
Rattus norvegicus LGALS3BP RGD RGD:620837
Bos taurus LGALS3BP VGNC VGNC:30853
Macaca mulatta LGALS3BP VGNC VGNC:74256
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