2. Gene
  3. LOXL2 - lysyl oxidase like 2 Gene

LOXL2 - lysyl oxidase like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：赖氨酰氧化酶样 2

种属: Homo sapiens

同用名: LOR; LOR2; WS9-14

基因 ID: 4017 | 基因类型: protein coding

关于 LOXL2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,296,897-23,404,120 (from NCBI)

This gene has 15 transcripts (splice variants), 289 orthologues and 15 paralogues. Broad expression in placenta (RPKM 21.2), fat (RPKM 16.1) and 20 other tissues.

功能概要

该基因编码赖氨酰氧化酶基因家族的一个成员。该家族的原型成员对结缔组织的生物发生至关重要，编码细胞外铜依赖性胺氧化酶，催化胶原蛋白和弹性蛋白交联形成的第一步。 C 末端高度保守的氨基酸序列似乎足以维持胺氧化酶活性，表明每个家族成员都可能保留此功能。 N 末端的保守性很差，可能在发育调节、衰老、肿瘤抑制、细胞生长控制和趋化性方面赋予每个家族成员额外的作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL2 基因产物(1)

mRNA Protein Name
NM_002318.3 NP_002309.1 lysyl oxidase homolog 2 precursor

LOXL2 蛋白结构

SRCR

SRCR: Scavenger receptor cysteine-rich domain (65 - 159)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (202 - 301)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (330 - 425)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (439 - 544)

Lysyl_oxidase

Lysyl_oxidase: Lysyl oxidase (548 - 749)

  • 0
  • 200
  • 400
  • 600
  • 774 a.a.
蛋白主名 其他名称

lysyl oxidase homolog 2

lysyl oxidase related 2

重组 LOXL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74770 LOXL2 Protein, Human (HEK293, His) Q9Y4K0 (M26-Q774) ≥95%
HY-P74771 LOXL2 Protein, Human (CHO, His) Q9Y4K0 (M26-Q774) ≥95%

关联疾病

疾病名称 别名
Hyperostosis Cranialis Interna

HCIN

Hyperostosis Cranalis Interna
Cutis Laxa

Generalized Elastolysis

Loose Skin

Dermatolysis

Dermatomegaly

Cutis Laxa Syndrome
Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat
Pelvic Inflammatory Disease

Pid
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-107422 Lenumlostat 99.52% Phase 2
HY-107422A Lenumlostat hydrochloride / Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99047 Simtuzumab Inhibitor 98.69% Phase 2
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101771A (2-Chloropyridin-4-yl)methanamine hydrochloride 99.70% 否
HY-138625 LOX-IN-3 Inhibitor 99.97% 否
HY-114286A PXS-5153A monohydrochloride Inhibitor 99.67% 否
HY-138625A LOX-IN-3 dihydrochloride Inhibitor 99.97% 否
HY-151499A PXS-6302 hydrochloride Inhibitor 99.83% 否
HY-N0554 Escin IA Inhibitor 99.59% 否
HY-130242 PXS-5120A 98.02% 否
HY-114286 PXS-5153A Inhibitor / 否
HY-151498 PXS-4787 Inhibitor / 否
HY-151498A PXS-4787 hydrochloride Inhibitor / 否
HY-151499 PXS-6302 Inhibitor / 否
HY-138625B LOX-IN-3 dihydrochloride monohydrate Inhibitor / 否
HY-RS07742 LOXL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LOXL2 MGD MGI:2137913
Bos taurus LOXL2 VGNC VGNC:30953
Rattus norvegicus LOXL2 RGD RGD:1308435
Canis familiaris LOXL2 VGNC VGNC:42739
Felis catus LOXL2 VGNC VGNC:68080
Others LOXL2 NCBI
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