BMAL1 - basic helix-loop-helix ARNT like 1 Gene

中文名称：基本的螺旋-环-螺旋 ARNT 样 1

种属: Homo sapiens

同用名: TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5

基因 ID: 406 | 基因类型: protein coding

关于 BMAL1

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:13,276,652-13,387,266 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 8.3), skin (RPKM 6.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种基本的螺旋-环-螺旋蛋白，与 CLOCK 形成异二聚体。这种异二聚体结合周期 (PER1、PER2、PER3) 和隐花色素 (CRY1、CRY2) 基因上游的 E-box 增强子元件并激活这些基因的转录。 PER 和 CRY 蛋白通过在反馈回路中与 CLOCK/ARNTL 复合物相互作用而异二聚化并抑制其自身的转录。该基因的缺陷与不育、糖异生和脂肪生成问题以及睡眠模式改变有关。该蛋白调节干扰素刺激的基因表达，是包括 COVID-19 在内的病毒感染的重要因素。[RefSeq 提供，2021 年 10 月]

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral Infection, including COVID-19. [provided by RefSeq, Oct 2021]

BMAL1 基因产物(27)

mRNA	Protein	Name
NM_001030272.3	NP_001025443.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
NM_001030273.3	NP_001025444.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b
NM_001178.6	NP_001169.3	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
NM_001297719.2	NP_001284648.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c
NM_001297722.2	NP_001284651.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c
NM_001297724.2	NP_001284653.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351804.1	NP_001338733.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
NM_001351805.2	NP_001338734.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform g
NM_001351806.2	NP_001338735.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform h
NM_001351807.2	NP_001338736.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e
NM_001351808.2	NP_001338737.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351809.2	NP_001338738.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i
NM_001351810.2	NP_001338739.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k
NM_001351811.2	NP_001338740.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform m
NM_001351812.2	NP_001338741.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform i
NM_001351813.2	NP_001338742.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform j
NM_001351814.2	NP_001338743.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform e
NM_001351815.2	NP_001338744.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
NM_001351816.2	NP_001338745.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351817.2	NP_001338746.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform k
NM_001351818.2	NP_001338747.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b
NM_001351819.2	NP_001338748.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform f
NM_001351820.2	NP_001338749.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351821.2	NP_001338750.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351822.2	NP_001338751.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d
NM_001351823.2	NP_001338752.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform n
NM_001351824.2	NP_001338753.1	aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	11441146	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	25936801	GOA
enables E-box binding	IDA IDA: 通过直接分析推断	12738229	GOA
enables Hsp90 protein binding	IDA IDA: 通过直接分析推断	9079689	GOA
enables aryl hydrocarbon receptor binding	IPI IPI: 通过物理相互作用推断	9079689	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11018023	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in circadian regulation of gene expression	IDA IDA: 通过直接分析推断	23229515	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11441146	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	21628546	GOA
involved in positive regulation of circadian rhythm	IDA IDA: 通过直接分析推断	23229515	GOA
involved in positive regulation of protein acetylation	IMP IMP: 通过突变表型推断	28985504	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20093779	GOA
involved in regulation of hair cycle	IMP IMP: 通过突变表型推断	24005054	GOA
involved in response to redox state	IDA IDA: 通过直接分析推断	11441146	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CLOCK-BMAL transcription complex	IPI IPI: 通过物理相互作用推断	23229515	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23229515	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BMAL1 蛋白结构

HLH

PAS

PAS_11

0
100
200
300
400
500
625 a.a.

蛋白主名

其他名称

aryl hydrocarbon receptor nuclear translocator-like protein 1

ARNT-like protein 1, brain and muscle

BMAL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BMAL1	O00327	HIF1A	Homo sapiens	D0VY79	Validated Y2H	25416956
种属内	BMAL1	O00327	HIF1A	Homo sapiens	D0VY79	Y2H Array	25416956
种属内	BMAL1	O00327	CLOCK	Homo sapiens	O15516	Anti Bait CoIP	28388406
种属内	BMAL1	O00327	CLOCK	Homo sapiens	O15516	Y2H Array	31515488
种属内	BMAL1	O00327	NPAS2	Homo sapiens	Q99743	Anti Tag CoIP	33961781
种属内	BMAL1	O00327	NPAS2	Homo sapiens	Q99743	Y2H Array	20211142

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bile Duct Cystadenoma

Cystadenoma Of The Bile Duct

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Apnea, Obstructive Sleep

Obstructive Sleep Apnea Syndrome	Obstructive Sleep Apnea
Sleep Apnea, Obstructive	Osa
Osas	Sleep Apnea/Hypopnea Syndrome
Sahs	Upper Airway Resistance Sleep Apnea Syndrome
Apnea, Obstructive	Obstructive Apnea
Osahs	Sleep Apnea Hypopnea Syndrome
Sleep Apnea Syndrome, Obstructive	Sleep Apnea Obstructive
Sleep Apnea Syndromes	Obstructive Sleep Apnoea Syndrome
Obstructive Sleep Apnoea, Adult	Osa - [Obstructive Sleep Apnoea]
Obstructive Sleep Apnoea, Paediatric	Obstructive Sleep Apnoea Hypopnoea Syndrome
Osa Syndrome	Sleep Apnoea Nos
[Sas] - Sleep Apnoea Syndrome	Sleep Apnoea Syndrome
[Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome	[Sahs] - Sleep Apnoea-Hypopnea Syndrome

Diabetes Mellitus

Diabetes

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148765	CLK8	Inhibitor	98.03%	否
HY-148711	STL1267	Activator	99.86%	否
HY-14414	GSK4112	Inhibitor	99.87%	否
HY-115672	KS15		99.40%	否
HY-RS01529	BMAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	BMAL1	VGNC	VGNC:99550
Felis catus	BMAL1	VGNC	VGNC:81906
Bos taurus	BMAL1	VGNC	VGNC:54628
Canis familiaris	BMAL1	VGNC	VGNC:52062
Rattus norvegicus	BMAL1	RGD	RGD:62003
Mus musculus	BMAL1	MGD	MGI:1096381

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BMAL1 - basic helix-loop-helix ARNT like 1 Gene

关于 BMAL1

功能概要

BMAL1 基因产物(27)

BMAL1 蛋白结构

BMAL1 蛋白互作信息

关联疾病

直系同源

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BMAL1 - basic helix-loop-helix ARNT like 1 Gene

关于 BMAL1

功能概要

BMAL1 基因产物(27)

BMAL1 蛋白结构

BMAL1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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