NPAS2 - neuronal PAS domain protein 2 Gene

中文名称：神经元 PAS 结构域蛋白 2

种属: Homo sapiens

同用名: MOP4; PASD4; bHLHe9

基因 ID: 4862 | 基因类型: protein coding

关于 NPAS2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,818,723-100,996,829 (from NCBI)

This gene has 12 transcripts (splice variants), 143 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 4.7), urinary bladder (RPKM 4.5) and 22 other tissues.

功能概要

该基因编码的蛋白质是基本螺旋-环-螺旋 (bHLH) -PAS 转录因子家族的成员。一种类似的小鼠蛋白可能在特定类型记忆的获得中发挥调节作用。它还可能作为哺乳动物前脑中分子钟的一部分发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

NPAS2 基因产物(1)

mRNA	Protein	Name
NM_002518.4	NP_002509.2	neuronal PAS domain-containing protein 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	11441146	GOA
enables Hsp90 protein binding	IDA IDA: 通过直接分析推断	9079689	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14645221	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	18819933	GOA
involved in positive regulation of DNA repair	IMP IMP: 通过突变表型推断	18819933	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11441146	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	18819933	GOA
involved in response to redox state	IDA IDA: 通过直接分析推断	11441146	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	14645221	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPAS2 蛋白结构

HLH

PAS

PAS_11

0
200
400
600
824 a.a.

蛋白主名

其他名称

neuronal PAS domain-containing protein 2

PAS domain-containing protein 4

NPAS2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NPAS2	Q99743	BMAL1	Homo sapiens	O00327-8	Y2H Array	24722188
Intra	NPAS2	Q99743	BMAL1	Homo sapiens	O00327-8	Y2H Prey Pooling	32296183
Intra	NPAS2	Q99743	BMAL1	Homo sapiens	O00327-8	Y2H Array	32296183
Intra	NPAS2	Q99743	BMAL2	Homo sapiens	Q8WYA1-3	Y2H Array	24722188
Intra	NPAS2	Q99743	BMAL2	Homo sapiens	Q8WYA1-3	Y2H Prey Pooling	32296183
Intra	NPAS2	Q99743	BMAL2	Homo sapiens	Q8WYA1-3	Y2H Array	32296183
Intra	NPAS2	Q99743	BMAL1	Homo sapiens	O00327	Anti Tag CoIP	33961781
Intra	NPAS2	Q99743	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	NPAS2	Q99743	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	NPAS2	Q99743	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	NPAS2	Q99743	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	NPAS2	Q99743	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	NPAS2	Q99743	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	NPAS2	Q99743	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	NPAS2	Q99743	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	NPAS2	Q99743	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09469	NPAS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NPAS2	RGD	RGD:1309681
Bos taurus	NPAS2	VGNC	VGNC:32190
Canis familiaris	NPAS2	VGNC	VGNC:43909
Felis catus	NPAS2	VGNC	VGNC:68526
Macaca mulatta	NPAS2	VGNC	VGNC:75378
Mus musculus	NPAS2	MGD	MGI:109232

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NPAS2 - neuronal PAS domain protein 2 Gene

关于 NPAS2

功能概要

NPAS2 基因产物(1)

NPAS2 蛋白结构

NPAS2 蛋白互作信息

关联疾病

直系同源

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NPAS2 - neuronal PAS domain protein 2 Gene

关于 NPAS2

功能概要

NPAS2 基因产物(1)

NPAS2 蛋白结构

NPAS2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z