1. Gene
  2. CAPRIN1 - cell cycle associated protein 1 Gene

CAPRIN1 - cell cycle associated protein 1 Gene

中文名称:细胞周期相关蛋白 1

种属: Homo sapiens

同用名: M11S1; GPIAP1; RNG105; GPIP137; GRIP137; p137GPI

基因 ID: 4076 | 基因类型: protein coding

关于 CAPRIN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,051,731-34,102,610 (from NCBI)

This gene has 17 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues.

功能概要

启用 RNA 结合活性。预计参与翻译的负调节和树突棘形态发生的正调节。位于细胞前缘和细胞质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Predicted to be involved in negative regulation of translation and positive regulation of dendritic spine morphogenesis. Located in cell leading edge and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CAPRIN1 基因产物(2)

mRNA Protein Name
NM_005898.5 NP_005889.3 caprin-1 isoform 1
NM_203364.3 NP_976240.1 caprin-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
34074792 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
17210633 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
31439799 GOA
enables molecular function activator activity IDA
IDA: 通过直接分析推断
32302570 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18005740 GOA
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
31439799 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
31439799 GOA
involved in non-membrane-bounded organelle assembly IDA
IDA: 通过直接分析推断
31439799 GOA
involved in positive regulation of stress granule assembly IDA
IDA: 通过直接分析推断
27022092 GOA
involved in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: 通过直接分析推断
31439799 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell leading edge IDA
IDA: 通过直接分析推断
28733330 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
28733330 GOA
is active in intracellular non-membrane-bounded organelle IDA
IDA: 通过直接分析推断
31439799 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CAPRIN1 蛋白结构

Caprin-1_C

Caprin-1_C: Cytoplasmic activation/proliferation-associated protein-1 C term (367 - 682)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
蛋白主名 其他名称

caprin-1

GPI-anchored membrane protein 1

CAPRIN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CAPRIN1 Q14444 G3BP1 Homo sapiens Q13283
Fluorescence
18005740
种属内
CAPRIN1 Q14444 G3BP1 Homo sapiens Q13283
FPS
34799561
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Moyamoya Angiopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CAPRIN1 VGNC VGNC:68117
Bos taurus CAPRIN1 VGNC VGNC:26751
Macaca mulatta CAPRIN1 VGNC VGNC:70692
Rattus norvegicus CAPRIN1 RGD RGD:1305707
Mus musculus CAPRIN1 MGD MGI:1858234
Canis familiaris CAPRIN1 VGNC VGNC:51857