MMP15 - matrix metallopeptidase 15 Gene

中文名称：基质金属肽酶 15

种属: Homo sapiens

同用名: MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP

关于 MMP15

功能概要

该基因编码肽酶 M10 家族和基质金属蛋白酶 (MMP) 膜型亚家族的成员。该家族中的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。该亚家族的成员包含一个跨膜结构域，表明这些蛋白质在细胞表面表达而不是分泌。编码的前原蛋白经过蛋白水解处理以产生成熟的蛋白酶。这种蛋白质可能在癌症进展中发挥作用。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature Protease. This protein may play a role in Cancer progression. [provided by RefSeq, Jan 2016]