MNT - MAX network transcriptional repressor Gene

中文名称：MAX 网络转录抑制因子

种属: Homo sapiens

同用名: ROX; MAD6; MXD6; bHLHd3; lncRNA-HAL

关于 MNT

功能概要

Myc/Max/Mad 网络包含一组转录因子，它们共同相互作用以调节基因特异性转录激活或抑制。该基因编码 Myc/Max/Mad 网络的一个蛋白质成员。在与 Max 蛋白异二聚化后，该蛋白具有一个碱性-螺旋-环-螺旋-拉链结构域 (bHLHzip) ，它与经典 DNA 序列 CANNTG (称为 E 盒) 结合。这种蛋白质可能是一种转录抑制因子和 Myc 依赖性转录激活和细胞生长的拮抗剂。该蛋白通过在其 N 末端 Sin3 相互作用域结合 DNA 结合蛋白来抑制转录。[RefSeq 提供，2008 年 7 月]

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]