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  2. NDN - necdin, MAGE family member Gene

NDN - necdin, MAGE family member Gene

中文名称:necdin, MAGE 家族成员

种属: Homo sapiens

同用名: PWCR; HsT16328

基因 ID: 4692 | 基因类型: protein coding

关于 NDN

Cytogenetic location: 15q11.2 Genomic coordinates (GRCh38): 15:23,685,400-23,687,305 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 161 orthologues, 37 paralogues and is associated with 5 phenotypes.

功能概要

该无内含子基因位于普拉德-威利综合征缺失区域。它是一个印记基因,仅由父系等位基因表达。对小鼠的研究表明,该基因编码的蛋白质可能会抑制有丝分裂后神经元的生长。[RefSeq 提供,2008 年 7 月]

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

NDN 基因产物(1)

mRNA Protein Name
NM_002487.3 NP_002478.1 necdin
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21364888 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NDN 蛋白结构

MAGE

MAGE: MAGE family (105 - 275)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
蛋白主名 其他名称

necdin

Prader-Willi syndrome chromosome region

NDN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NDN Q99608 EID1 Homo sapiens Q9Y6B2
Y2H Array
24722188
Intra NDN Q99608 SYAP1 Homo sapiens Q96A49
BioID
32529326
Intra NDN Q99608 PAIP2 Homo sapiens Q9BPZ3
BioID
32529326
Intra NDN Q99608 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra NDN Q99608 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra NDN Q99608 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra NDN Q99608 TP53 Homo sapiens P04637
Y2H Array
24722188
Intra NDN Q99608 NEFL Homo sapiens P07196
Y2H Array
24722188
Intra NDN Q99608 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra NDN Q99608 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra NDN Q99608 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra NDN Q99608 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra NDN Q99608 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra NDN Q99608 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Prader-Willi Syndrome Due To Paternal Deletion Of 15q11q13 Type 1
Prader-Willi Syndrome Due To Paternal Deletion Of 15q11q13 Type 2
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal

Schaaf-Yang Syndrome

Prader-Willi-Like Syndrome

Chitayat-Hall Syndrome

SHFYNG

Pwls

Magel2-Related Prader-Willi-Like Syndrome

Magel2-Related Pwls

Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies

Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A

Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies

Pws Due To A Point Mutation

Pws Due To Point Mutation

Prader-Willi Syndrome Due To A Point Mutation

Prader-Willi Syndrome Due To Point Mutation

Pws-Like

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Central Precocious Puberty

Cpp

Gonadotropin-Dependant Precocious Puberty

Gonadotropin-Dependent Precocious Puberty

Precocious Puberty, Central

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14

Temple Syndrome Due To Paternal 14q32.2 Microdeletion

Paternal Del(14)(Q32.2)

Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

Upd(14)Mat

Silver-Russell Syndrome 1

Silver-Russell Syndrome

Russell-Silver Syndrome

Silver-Russell Dwarfism

Rss

SRS1

Srs

Silver Russell Dwarfism

Russell Silver Syndrome

Silver Russell Syndrome

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus NDN VGNC VGNC:68434
Macaca mulatta NDN VGNC VGNC:75149
Mus musculus NDN MGD MGI:97290
Bos taurus NDN VGNC VGNC:31936
Canis familiaris NDN VGNC VGNC:43675
Rattus norvegicus NDN RGD RGD:1310526