NDUFB10 - NADH:ubiquinone oxidoreductase subunit B10 Gene

中文名称：NADH：泛醌氧化还原酶亚基 B10

种属: Homo sapiens

同用名: PDSW; MC1DN35

基因 ID: 4716 | 基因类型: protein coding

关于 NDUFB10

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,959,538-1,961,975 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 91.0), kidney (RPKM 64.3) and 25 other tissues.

功能概要

参与线粒体呼吸链复合物 I 的组装。位于线粒体内膜。线粒体呼吸链复合体 I 的一部分。与核型线粒体复合体 I 缺陷 35 有关。[由基因组资源联盟提供，2022 年 4 月]

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 35. [provided by Alliance of Genome Resources, Apr 2022]

NDUFB10 基因产物(1)

mRNA	Protein	Name
NM_004548.3	NP_004539.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14557246	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: 通过突变表型推断	27626371	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	28844695	GOA
located in mitochondrial inner membrane	IMP IMP: 通过突变表型推断	28040730	GOA
part of respiratory chain complex I	IDA IDA: 通过直接分析推断	12611891	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDUFB10 蛋白结构

NDUFB10

0
100
172 a.a.

蛋白主名

其他名称

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

CI-PDSW

NDUFB10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NDUFB10	O96000	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
种属内	NDUFB10	O96000	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
种属内	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
种属内	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
种属内	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
种属内	NDUFB10	O96000	SSB	Homo sapiens	P05455	Y2H Pooling	32814053
种属内	NDUFB10	O96000	SSB	Homo sapiens	P05455	Validated Y2H	32814053
种属内	NDUFB10	O96000	SSB	Homo sapiens	P05455	Y2H Array	32814053
种属内	NDUFB10	O96000	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	NDUFB10	O96000	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	NDUFB10	O96000	HTT	Homo sapiens	P42858	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

NDUFB10 抗体

目录号	产品名	应用	反应物种
HY-P81585	NDUFB10 Antibody (YA1330)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

关联疾病

疾病名称

别名

Mitochondrial Complex I Deficiency, Nuclear Type 35

MC1DN35	Mitochondrial Complex 1 Deficiency, Nuclear Type 35
Nuclear Type Mitochondrial Complex I Deficiency 35

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Mitochondrial Dna Depletion Syndrome 9

MTDPS9	Fatal Infantile Lactic Acidosis
Lactic Acidosis, Fatal Infantile, Formerly	Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria	Mitochondrial Dna Depletion Syndrome, Type 9
Lactic Acidosis, Fatal Infantile

Nuclear Type Mitochondrial Complex I Deficiency

Mc1dn	Mitochondrial Complex I Deficiency, Nuclear Type
Mitochondrial Complex I Deficiency, Nuclear

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Leukodystrophy

Leukodystrophies

Myopathy

Muscular Diseases

Myopathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09145	NDUFB10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NDUFB10	VGNC	VGNC:82556
Mus musculus	NDUFB10	MGD	MGI:1915592
Canis familiaris	NDUFB10	VGNC	VGNC:43699
Rattus norvegicus	NDUFB10	RGD	RGD:1310782
Macaca mulatta	NDUFB10	VGNC	VGNC:75155
Bos taurus	NDUFB10	VGNC	VGNC:31960

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4