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  2. RPL10A - ribosomal protein L10a Gene

RPL10A - ribosomal protein L10a Gene

中文名称:核糖体蛋白 L10a

种属: Homo sapiens

同用名: L10A; CSA19; NEDD6; Csa-19

基因 ID: 4736 | 基因类型: protein coding

关于 RPL10A

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,468,401-35,470,780 (from NCBI)

This gene has 5 transcripts (splice variants), 160 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 957.8), bone marrow (RPKM 440.0) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器,由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 L1P 家族。它位于细胞质中。该基因的表达在胸腺中被免疫抑制药物环孢菌素 A (CsA) 下调。对小鼠的研究表明,在发育过程中,核糖体蛋白 L10a 基因的表达在神经前体细胞中下调。该基因以前被称为 NEDD6 (神经前体细胞表达,发育下调 6) ,但已更名为 RPL10A (核糖体蛋白 10a) 。作为典型的编码核糖体蛋白的基因,该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供,2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL10A 基因产物(1)

mRNA Protein Name
NM_007104.5 NP_009035.3 60S ribosomal protein L10a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24725412 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translation IDA
IDA: 通过直接分析推断
25957688 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
25957688 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPL10A 蛋白结构

Ribosomal_L1

Ribosomal_L1: Ribosomal protein L1p/L10e family (22 - 212)

  • 0
  • 100
  • 200
  • 217 a.a.
蛋白主名 其他名称

60S ribosomal protein L10a

NEDD-6

RPL10A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPL10A P62906 RPS3A Homo sapiens P61247 33961781
种属内
RPL10A P62906 RPL11 Homo sapiens P62913 30021884
种属内
RPL10A P62906 RGS17 Homo sapiens Q9UGC6 25416956
种属内
RPL10A P62906 RGS17 Homo sapiens Q9UGC6 32296183
种属内
RPL10A P62906 RGS17 Homo sapiens Q9UGC6 32296183
种属内
RPL10A P62906 RGS17 Homo sapiens Q9UGC6 25416956
种属内
RPL10A P62906 RGS17 Homo sapiens Q9UGC6 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

RPL10A 抗体

目录号 产品名 应用 反应物种
HY-P82135 RPL10A Antibody (YA1880) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPL10A RGD RGD:620497
Macaca mulatta RPL10A VGNC VGNC:83460
Felis catus RPL10A VGNC VGNC:105242
Mus musculus RPL10A MGD MGI:1343877
Bos taurus RPL10A VGNC VGNC:54233
Canis familiaris RPL10A VGNC VGNC:105240
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