2. Gene
  3. RPS3A - ribosomal protein S3A Gene

RPS3A - ribosomal protein S3A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S3A

种属: Homo sapiens

同用名: S3A; FTE1; MFTL

基因 ID: 6189 | 基因类型: protein coding

关于 RPS3A

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:151,099,628-151,104,642 (from NCBI)

This gene has 14 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in ovary (RPKM 854.6), bone marrow (RPKM 571.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 S3AE 家族。它位于细胞质中。在 v-fos 转化的大鼠细胞中破坏编码大鼠核糖体蛋白 S3a (也称为 v-fos 转化效应蛋白) 的基因会导致转化表型的逆转。该基因与 U73A 和 U73B 小核仁 RNA 基因共转录，这两个基因分别位于其第四和第三个内含子中。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 5 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

RPS3A 基因产物(2)

mRNA Protein Name
NM_001006.5 NP_000997.1 40S ribosomal protein S3a isoform 1
NM_001267699.2 NP_001254628.1 40S ribosomal protein S3a isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
16213212 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11823430 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
9566973 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
involved in translation IMP
IMP: 通过突变表型推断
8877097 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11823430 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
15572026 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS3A 蛋白结构

Ribosomal_S3Ae

Ribosomal_S3Ae: Ribosomal S3Ae family (13 - 222)

  • 0
  • 100
  • 200
  • 264 a.a.
蛋白主名 其他名称

40S ribosomal protein S3a

fte-1

RPS3A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS3A P61247 HSP90AA1 Homo sapiens P07900
Y2H Pooling
16169070
种属内
RPS3A P61247 RPS14 Homo sapiens P62263
Crosslink
30021884
种属内
RPS3A P61247 RPL10A Homo sapiens P62906
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia 6

DBA6

Aase-Smith Syndrome Ii

Aase Syndrome

Aase Smith Syndrome 2

Rpl5-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 6

Diamond-Blackfan Anemia 1
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies

FENIB

Encephalopathy, Familial, With Collins Bodies

Familial Dementia With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Collins Bodies
Tracheitis

Acute Tracheitis

Chronic Tracheitis

Bacterial Tracheitis

Acute Tracheitis Nos

Tracheitis Nos

Tracheal Inflammation
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12243 RPS3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RPS3A VGNC VGNC:79996
Rattus norvegicus RPS3A RGD RGD:62078
Bos taurus RPS3A VGNC VGNC:55759
Mus musculus RPS3A MGD MGI:1202063
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z