NFATC3 - nuclear factor of activated T cells 3 Gene

中文名称：活化 T 细胞核因子 3

种属: Homo sapiens

同用名: NFAT4; NFATX; NF-AT4c; n339260

基因 ID: 4775 | 基因类型: protein coding

关于 NFATC3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,085,370-68,229,259 (from NCBI)

This gene has 22 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 17.4), lymph node (RPKM 16.5) and 25 other tissues.

功能概要

该基因的产物是活化 T 细胞 DNA 结合转录复合物核因子的成员。该复合物至少由两个成分组成：在 T 细胞受体 (TCR) 刺激后转移到细胞核的预先存在的胞质成分和可诱导的核成分。这个家族的其他成员也参与形成这个复合体。该基因的产物在 T 细胞和未成熟胸腺细胞中的基因表达调节中发挥作用。已经为该基因鉴定了几种编码不同亚型的转录物变体。[RefSeq 提供，2010 年 11 月]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

NFATC3 基因产物(3)

mRNA	Protein	Name
NM_004555.4	NP_004546.1	nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
NM_173163.3	NP_775186.1	nuclear factor of activated T-cells, cytoplasmic 3 isoform 3
NM_173165.3	NP_775188.1	nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15173172	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	15173172	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: 通过遗传相互作用推断	23543060	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15173172	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24330068	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of miRNA transcription	IGI IGI: 通过遗传相互作用推断	23543060	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: 通过直接分析推断	23853098	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18815128	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15173172	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18815128	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12370307	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFATC3 蛋白结构

RHD_DNA_bind

0
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1075 a.a.

蛋白主名

其他名称

nuclear factor of activated T-cells, cytoplasmic 3

NF-ATc3

NFATC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NFATC3	Q12968	RAF1	Homo sapiens	P04049	Anti Bait CoIP	24330068
种属内	NFATC3	Q12968	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	33961781
种属内	NFATC3	Q12968	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukostasis

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09241	NFATC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NFATC3	VGNC	VGNC:43769
Macaca mulatta	NFATC3	VGNC	VGNC:75328
Bos taurus	NFATC3	VGNC	VGNC:32033
Felis catus	NFATC3	VGNC	VGNC:68471
Rattus norvegicus	NFATC3	RGD	RGD:1308692
Mus musculus	NFATC3	MGD	MGI:103296

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NFATC3 - nuclear factor of activated T cells 3 Gene

关于 NFATC3

功能概要

NFATC3 基因产物(3)

NFATC3 蛋白结构

NFATC3 蛋白互作信息

关联疾病

直系同源

热门区域

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NFATC3 - nuclear factor of activated T cells 3 Gene

关于 NFATC3

功能概要

NFATC3 基因产物(3)

NFATC3 蛋白结构

NFATC3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z