NFIX - nuclear factor I X Gene

中文名称：核因子 IX

种属: Homo sapiens

同用名: CTF; NF1A; MALNS; NF1-X; MRSHSS; NF-I/X; SOTOS2

基因 ID: 4784 | 基因类型: protein coding

关于 NFIX

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,995,475-13,098,796 (from NCBI)

This gene has 17 transcripts (splice variants), 283 orthologues, 3 paralogues and is associated with 6 phenotypes. Ubiquitous expression in brain (RPKM 36.5), fat (RPKM 32.4) and 23 other tissues.

功能概要

该基因编码的蛋白质是一种转录因子，可结合病毒和细胞启动子中的回文序列 5'-TTGGCNNNNNGCCAA-3。编码的蛋白质还可以在体外刺激腺病毒复制。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

NFIX 基因产物(10)

mRNA	Protein	Name
NM_001271043.2	NP_001257972.1	nuclear factor 1 X-type isoform 1
NM_001271044.3	NP_001257973.1	nuclear factor 1 X-type isoform 3
NM_001365902.3	NP_001352831.1	nuclear factor 1 X-type isoform 4
NM_001365982.2	NP_001352911.1	nuclear factor 1 X-type isoform 5
NM_001365983.2	NP_001352912.1	nuclear factor 1 X-type isoform 6
NM_001365984.2	NP_001352913.1	nuclear factor 1 X-type isoform 7
NM_001365985.2	NP_001352914.1	nuclear factor 1 X-type isoform 8
NM_001378404.1	NP_001365333.1	nuclear factor 1 X-type isoform 9
NM_001378405.1	NP_001365334.1	nuclear factor 1 X-type isoform 10
NM_002501.4	NP_002492.2	nuclear factor 1 X-type isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21953450	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19706729	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19706729	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFIX 蛋白结构

NfI_DNAbd_pre-N

MH1

CTF_NFI

0
100
200
300
400
502 a.a.

蛋白主名

其他名称

nuclear factor 1 X-type

CCAAT-box-binding transcription factor

NFIX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NFIX	Q14938	QRICH1	Homo sapiens	Q2TAL8	Y2H Prey Pooling	25416956
种属内	NFIX	Q14938	QRICH1	Homo sapiens	Q2TAL8	Y2H Array	25416956
种属内	NFIX	Q14938	ZNF614	Homo sapiens	Q8N883	Y2H Prey Pooling	25416956
种属内	NFIX	Q14938	ZNF614	Homo sapiens	Q8N883	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Malan Syndrome

Malan Overgrowth Syndrome	MALNS
Sotos Syndrome 2	Sotos Syndrome 2, Formerly
Sotos2, Formerly	Sotos2

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Sotos Syndrome 2

Sotos2

Sotos Syndrome, Type 2

19p13.3 Microduplication Syndrome

Dup(19)(P13.13)

Laryngomalacia

Congenital Laryngomalacia	Congenital Laryngeal Stridor
Laryngomalacia Congenital	Floppy Epiglottis

Exophthalmos

Proptosis

Megalocornea

Isolated Congenital Megalocornea	Congenital Anterior Megalophthalmia
Anterior Megalophthalmos	Mgc1
Mgcn	Congenital Keratoglobus

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Sotos Syndrome 1

Sotos1	Sotos Syndrome, Type 1
Sotos' Syndrome

Sotos Syndrome 3

Sotos3

Sotos Syndrome, Type 3

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Cornelia De Lange Syndrome 5

CDLS5

Cornelia De Lange Syndrome, Type 5

Cellular Neurofibroma

Developmental And Epileptic Encephalopathy 60

DEE60	Epileptic Encephalopathy, Early Infantile, 60
Eiee60	Developmental And Epileptic Encephalopathy, 60
Early Infantile Epileptic Encephalopathy 60

Sotos Syndrome

Cerebral Gigantism	SOTOS
Chromosome 5q35 Deletion Syndrome	Sotos Syndrome 1, Formerly
Sotos1, Formerly	Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development
Sotos Sequence	Sotos' Syndrome
Sotos1	Sotos Syndrome 1

Marshall Syndrome

MRSHS	Deafness, Myopia, Cataract, Saddle Nose-Marshall Type
Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis	Pfapa Syndrome
Pfapa	Marshall Syndrome With Periodic Fever
Periodic Fever-Aphtous Stomatitis-Pharyngitis-Adenopathy Syndrome

Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11	DEE11
Eiee11	Developmental And Epileptic Encephalopathy, 11
Early Infantile Epileptic Encephalopathy 11	Encephalopathy, Developmental And Epileptic, Type 11

Scoliosis

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09253	NFIX Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NFIX	MGD	MGI:97311
Canis familiaris	NFIX	VGNC	VGNC:43779
Rattus norvegicus	NFIX	RGD	RGD:69080
Bos taurus	NFIX	VGNC	VGNC:32042
Felis catus	NFIX	VGNC	VGNC:68479
Macaca mulatta	NFIX	VGNC	VGNC:75338

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NFIX - nuclear factor I X Gene

关于 NFIX

功能概要

NFIX 基因产物(10)

NFIX 蛋白结构

NFIX 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

NFIX - nuclear factor I X Gene

关于 NFIX

功能概要

NFIX 基因产物(10)

NFIX 蛋白结构

NFIX 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z