NKX3-1 - NK3 homeobox 1 Gene

中文名称：NK3 同源框 1

种属: Homo sapiens

同用名: NKX3; BAPX2; NKX3A; NKX3.1

基因 ID: 4824 | 基因类型: protein coding

关于 NKX3-1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,678,693-23,682,938 (from NCBI)

This gene has 2 transcripts (splice variants), 168 orthologues and 13 paralogues. Biased expression in prostate (RPKM 180.9) and testis (RPKM 17.6).

功能概要

该基因编码含有同源框的转录因子。该转录因子作为前列腺组织中上皮细胞生长的负调节因子发挥作用。该基因的异常表达与前列腺肿瘤进展相关。交替剪接导致该基因的多个转录变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

NKX3-1 基因产物(2)

mRNA	Protein	Name
NM_001256339.1	NP_001243268.1	homeobox protein Nkx-3.1 isoform 2
NM_006167.4	NP_006158.2	homeobox protein Nkx-3.1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	20855495	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	18794125	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	18296735	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	18974119	GOA
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: 通过直接分析推断	19266349	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	18974119	GOA
enables nuclear estrogen receptor binding	IDA IDA: 通过直接分析推断	18794125	GOA
enables nuclear receptor activity	IDA IDA: 通过直接分析推断	19886863	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17234752	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19780584	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19263243	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	18794125	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	20395202	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	17486276	GOA
involved in androgen receptor signaling pathway	IDA IDA: 通过直接分析推断	19886863	GOA
involved in cellular response to hypoxia	IDA IDA: 通过直接分析推断	21056661	GOA
involved in cellular response to interleukin-1	IEP IEP: 通过表达模式推断	18757402	GOA
involved in cellular response to steroid hormone stimulus	IDA IDA: 通过直接分析推断	19886863	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: 通过表达模式推断	18757402	GOA
involved in cellular response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	18757402	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18794125	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	18360715	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17486276	GOA
involved in negative regulation of gene expression	IDA IDA: 通过直接分析推断	17486276	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19597465	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	18360715	GOA
involved in positive regulation of androgen secretion	IDA IDA: 通过直接分析推断	19886863	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: 通过直接分析推断	20599703	GOA
involved in positive regulation of cell division	IMP IMP: 通过突变表型推断	20855495	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	18360715	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	20599703	GOA
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	17486276	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	20716579	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	17486276	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	20855495	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	20395202	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	20395202	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19797053	GOA
involved in regulation of protein localization	IMP IMP: 通过突变表型推断	20395202	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	18757402	GOA
located in site of DNA damage	IDA IDA: 通过直接分析推断	20395202	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NKX3-1 蛋白结构

Homeobox

0
100
200
234 a.a.

蛋白主名

其他名称

homeobox protein Nkx-3.1

NK homeobox, family 3, A

NKX3-1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NKX3-1	Q99801	CD200R1L	Homo sapiens	Q6Q8B3	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	CD200R1L	Homo sapiens	Q6Q8B3	Y2H Array	32296183
Intra	NKX3-1	Q99801	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	NKX3-1	Q99801	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	NKX3-1	Q99801	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	32296183
Intra	NKX3-1	Q99801	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	32296183
Intra	NKX3-1	Q99801	TOP1	Homo sapiens	P11387	Pull Down	17234752
Intra	NKX3-1	Q99801	TOP1	Homo sapiens	P11387	Confocal	17234752

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Rete Testis Neoplasm

Rete Testis Adenocarcinoma

Adenocarcinoma Of Rete Testis

Adenocarcinoma Of The Rete Testis

Salivary Gland Mucinous Adenocarcinoma

Anal Spasm

Proctospasm	Anorectal Spasm
Rectal Spasm

Cervical Adenoid Basal Carcinoma

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Prostatitis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Atrophy Of Prostate

Adenoid Basal Cell Carcinoma

Skin Adenoid Basal Cell Carcinoma

Basal Cell Carcinoma - Adenoid

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Bladder Small Cell Carcinoma

Small Cell Bladder Cancer	Small Cell Carcinoma Of The Bladder
Poorly Differentiated Neuroendocrine Carcinoma Of The Bladder	Sccb
Small Cell Bladder Carcinoma	Small Cell Carcinoma Of The Urinary Bladder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09333	NKX3-1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NKX3-1	VGNC	VGNC:32105
Felis catus	NKX3-1	VGNC	VGNC:78533
Mus musculus	NKX3-1	MGD	MGI:97352
Rattus norvegicus	NKX3-1	RGD	RGD:1305369
Macaca mulatta	NKX3-1	VGNC	VGNC:75355

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