2. Gene
  3. CCN3 - cellular communication network factor 3 Gene

CCN3 - cellular communication network factor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蜂窝通信网络因素 3

种属: Homo sapiens

同用名: NOV; NOVh; IBP-9; IGFBP9; IGFBP-9

基因 ID: 4856 | 基因类型: protein coding

关于 CCN3

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,416,446-119,424,434 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 5 paralogues. Biased expression in adrenal (RPKM 648.6) and prostate (RPKM 11.0).

功能概要

由该基因编码的蛋白质是一种小的分泌型富含半胱氨酸的蛋白质，是调节蛋白 CCN 家族的成员。 CNN 家族蛋白与细胞外基质相关，在心血管和骨骼发育、纤维化和癌症发展中发挥重要作用。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and Cancer development. [provided by RefSeq, Feb 2009]

CCN3 基因产物(1)

mRNA Protein Name
NM_002514.4 NP_002505.1 CCN family member 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
12050162 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
12695522 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9927660 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
12695522 GOA
involved in cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
12695522 GOA
involved in cell chemotaxis IDA
IDA: 通过直接分析推断
15611078 GOA
involved in chondrocyte differentiation IMP
IMP: 通过突变表型推断
21871891 GOA
involved in endothelial cell chemotaxis IDA
IDA: 通过直接分析推断
12695522 GOA
involved in endothelial cell-cell adhesion IDA
IDA: 通过直接分析推断
12695522 GOA
involved in fibroblast migration IDA
IDA: 通过直接分析推断
15611078 GOA
involved in hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
17463287 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
15181016 GOA
involved in negative regulation of chondrocyte proliferation IMP
IMP: 通过突变表型推断
21871891 GOA
involved in negative regulation of monocyte chemotaxis IMP
IMP: 通过突变表型推断
21063504 GOA
involved in negative regulation of myotube differentiation IDA
IDA: 通过直接分析推断
12050162 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21063504 GOA
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
12050162 GOA
involved in positive regulation of ossification IDA
IDA: 通过直接分析推断
38987585 GOA
involved in smooth muscle cell migration IDA
IDA: 通过直接分析推断
20139355 GOA
involved in smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
20139355 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IMP
IMP: 通过突变表型推断
15181016 GOA
located in gap junction IMP
IMP: 通过突变表型推断
15181016 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCN3 蛋白结构

IGFBP

IGFBP: Insulin-like growth factor binding protein (35 - 89)

VWC

VWC: von Willebrand factor type C domain (110 - 173)

TSP_1

TSP_1: Thrombospondin type 1 domain (209 - 249)

Cys_knot

Cys_knot: Cystine-knot domain (262 - 347)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

CCN family member 3

IGF-binding protein 9

关联疾病

疾病名称 别名
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Rhabdomyosarcoma
Marfan Syndrome

MFS

Mfs1

Marfan'S Syndrome

Marfan Syndrome Type 1

Marfan Syndrome, Type I

Mass Phenotype

Contractural Arachnodactyly

Mass Syndrome

Octd

Overlap Connective Tissue Disease

Marfanoid Hypermobility Syndrome

Marfan Disease
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02112 CCN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CCN3 RGD RGD:621553
Mus musculus CCN3 MGD MGI:109185
Felis catus CCN3 VGNC VGNC:68520
Bos taurus CCN3 VGNC VGNC:57785
Macaca mulatta CCN3 VGNC VGNC:70932
Canis familiaris CCN3 VGNC VGNC:56074
Others CCN3 NCBI
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