NOVA1 - NOVA alternative splicing regulator 1 Gene

中文名称：NOVA 可变剪接调节器 1

种属: Homo sapiens

同用名: Nova-1

基因 ID: 4857 | 基因类型: protein coding

关于 NOVA1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:26,443,090-26,598,033 (from NCBI)

This gene has 13 transcripts (splice variants), 295 orthologues and 12 paralogues. Biased expression in brain (RPKM 10.5), fat (RPKM 4.3) and 12 other tissues.

功能概要

该基因编码一种神经元特异性 RNA 结合蛋白，是副肿瘤疾病抗原 Nova 家族的成员，可被副肿瘤抗体识别和抑制。这些抗体存在于副肿瘤性眼阵挛性共济失调、乳腺癌和小细胞肺癌患者的血清中。已经描述了编码不同亚型的选择性剪接转录物。[RefSeq 提供，2008 年 7 月]

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic Antibodies. These Antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast Cancer, and small cell lung Cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

NOVA1 基因产物(12)

mRNA	Protein	Name
NM_001366390.2	NP_001353319.1	RNA-binding protein Nova-1 isoform 4
NM_001366391.2	NP_001353320.1	RNA-binding protein Nova-1 isoform 5
NM_001366392.2	NP_001353321.1	RNA-binding protein Nova-1 isoform 6
NM_001366393.2	NP_001353322.1	RNA-binding protein Nova-1 isoform 7
NM_001366394.2	NP_001353323.1	RNA-binding protein Nova-1 isoform 8
NM_001366395.2	NP_001353324.1	RNA-binding protein Nova-1 isoform 5
NM_001366396.2	NP_001353325.1	RNA-binding protein Nova-1 isoform 5
NM_001366397.2	NP_001353326.1	RNA-binding protein Nova-1 isoform 4
NM_001366398.2	NP_001353327.1	RNA-binding protein Nova-1 isoform 5
NM_002515.3	NP_002506.2	RNA-binding protein Nova-1 isoform 1
NM_006489.3	NP_006480.2	RNA-binding protein Nova-1 isoform 2
NM_006491.3	NP_006482.1	RNA-binding protein Nova-1 isoform 3

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	27733149	GOA
enables sequence-specific mRNA binding	IDA IDA: 通过直接分析推断	10811881	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOVA1 蛋白结构

KH_1

0
100
200
300
400
507 a.a.

蛋白主名

其他名称

RNA-binding protein Nova-1

neuro-oncological ventral antigen 1

NOVA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NOVA1	P51513	HTR6	Homo sapiens	P50406	Y2H	30853821
种属内	NOVA1	P51513	HTR6	Homo sapiens	P50406	Pull Down	30853821
种属内	NOVA1	P51513	HTR6	Homo sapiens	P50406	Confocal	30853821
种属内	NOVA1	P51513	HTR6	Homo sapiens	P50406	Anti Tag CoIP	30853821

种属间: 跨种属相互作用 种属内: 同种属相互作用

NOVA1 抗体

目录号	产品名	应用	反应物种
HY-P81676	Nova1 Antibody (YA1421)	WB, IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Myoclonus

Cutaneous Adenocystic Carcinoma

Adenoid Cystic Eccrine Carcinoma	Adenoid Cystic Carcinoma Of The Skin
Adenoid Cystic Eccrine Carcinoma Of Skin

Partial Fetal Alcohol Syndrome

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09455	NOVA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NOVA1	RGD	RGD:621345
Bos taurus	NOVA1	VGNC	VGNC:84869
Macaca mulatta	NOVA1	VGNC	VGNC:75373
Felis catus	NOVA1	VGNC	VGNC:68521
Canis familiaris	NOVA1	VGNC	VGNC:43902
Mus musculus	NOVA1	MGD	MGI:104297

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NOVA1 - NOVA alternative splicing regulator 1 Gene

关于 NOVA1

功能概要

NOVA1 基因产物(12)

NOVA1 蛋白结构

NOVA1 蛋白互作信息

NOVA1 抗体

关联疾病

直系同源

热门区域

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NOVA1 - NOVA alternative splicing regulator 1 Gene

关于 NOVA1

功能概要

NOVA1 基因产物(12)

NOVA1 蛋白结构

NOVA1 蛋白互作信息

NOVA1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z