DDR2 - discoidin domain receptor tyrosine kinase 2 Gene

中文名称：盘基蛋白结构域受体酪氨酸激酶 2

种属: Homo sapiens

同用名: TKT; WRCN; MIG20a; NTRKR3; TYRO10

基因 ID: 4921 | 基因类型: protein coding

关于 DDR2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,630,863-162,787,405 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 53 paralogues and is associated with 106 phenotypes. Broad expression in fat (RPKM 30.2), adrenal (RPKM 24.5) and 20 other tissues.

功能概要

该基因编码受体酪氨酸激酶 (RTK) 蛋白家族的盘基蛋白结构域受体亚类的成员。 RTK 在细胞与其微环境的通讯中起着关键作用。编码的蛋白质是一种胶原蛋白诱导的受体，可激活参与细胞粘附、增殖和细胞外基质重塑的信号转导通路。这种蛋白质在多种细胞类型中表达，可能还参与伤口修复和调节肿瘤生长和侵袭性。该基因的突变是短肢手型脊柱骨骺发育不良的原因。[RefSeq 提供，2017 年 8 月]

This gene encodes a member of the Discoidin Domain Receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

DDR2 基因产物(8)

mRNA	Protein	Name
NM_001354983.2	NP_001341912.1	discoidin domain-containing receptor 2 precursor
NM_001014796.3	NP_001014796.1	discoidin domain-containing receptor 2 precursor
NM_001354982.2	NP_001341911.1	discoidin domain-containing receptor 2 precursor
XM_011509587.3	XP_011507889.1	discoidin domain-containing receptor 2 isoform X1
XM_047421554.1	XP_047277510.1	discoidin domain-containing receptor 2 isoform X1
XM_047421565.1	XP_047277521.1	discoidin domain-containing receptor 2 isoform X2
XM_011509588.4	XP_011507890.1	discoidin domain-containing receptor 2 isoform X3
NM_006182.4	NP_006173.2	discoidin domain-containing receptor 2 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables collagen binding	IDA IDA: 通过直接分析推断	20004161	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17703188	GOA
enables protein tyrosine kinase collagen receptor activity	IDA IDA: 通过直接分析推断	9659899	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	20004161	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: 通过直接分析推断	16186108	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	20004161	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	20564243	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	20564243	GOA
involved in positive regulation of protein kinase activity	IMP IMP: 通过突变表型推断	20564243	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	16186108	GOA
involved in regulation of bone mineralization	IMP IMP: 通过突变表型推断	20564243	GOA
involved in regulation of tissue remodeling	IMP IMP: 通过突变表型推断	30449416	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDR2 蛋白结构

F5_F8_type_C

Pkinase_Tyr

0
200
400
600
800
855 a.a.

蛋白主名

其他名称

discoidin domain-containing receptor 2

CD167 antigen-like family member B	cell migration-inducing protein 20
discoidin domain receptor 2	discoidin domain receptor family, member 2
discoidin domain-containing receptor tyrosine kinase 2	hydroxyaryl-protein kinase
migration-inducing gene 16 protein	neurotrophic tyrosine kinase receptor related 3
receptor protein-tyrosine kinase TKT	tyrosine-protein kinase TYRO10

重组 DDR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76867	DDR2 Protein, Human (sf9, His-GST)	Q16832 (R422-E855)	≥95%
HY-P76868	DDR2 Protein, Human (HEK293, Fc)	Q16832/NP_001014796.1 (K22-R399)	≥95%
HY-P76869	DDR2 Protein, Human (HEK293, His)	Q16832/NP_001014796.1 (K22-R399)	≥95%

关联疾病

疾病名称

别名

Pectus Excavatum

Funnel Chest

Congenital Pectus Excavatum

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Warburg-Cinotti Syndrome

WRCN

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Adenosquamous Lung Carcinoma

Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma

Brachydactyly

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome	Smed-Sl
Smed-Sl/Ac	Smed Short Limb-Abnormal Calcification Type
Smed Short Limb-Hand Type	Spondylometaepiphyseal Dysplasia Short Limb-Hand Type
Smed, Type Ii	Smed Type 2
Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type	Smed, Short Limb-Hand Type
Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type	Smed, Short Limb-Abnormal Calcification Type
Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification	Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type
SEMD-SL	Smed Type Ii
Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Malignant Squamous Cell Tumor
Squamous Carcinoma	Squamous Cell Epithelioma
Squamous Cell Skin Cancer	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Keloid Formation

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114169	WRG-28	Inhibitor	99.34%	否
HY-135401	VU6015929	Inhibitor	99.50%	否
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	否
HY-114173	DDR1-IN-4	Inhibitor	98.19%	否
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	否
HY-14979A	ML786 dihydrochloride	Inhibitor	/	否
HY-162102	DDR1-IN-8	Inhibitor	/	否
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DDR2	RGD	RGD:619855
Bos taurus	DDR2	VGNC	VGNC:27953
Macaca mulatta	DDR2	VGNC	VGNC:71758
Felis catus	DDR2	VGNC	VGNC:61395
Mus musculus	DDR2	MGD	MGI:1345277
Canis familiaris	DDR2	VGNC	VGNC:39842
Others	DDR2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DDR2 - discoidin domain receptor tyrosine kinase 2 Gene

关于 DDR2

功能概要

DDR2 基因产物(8)

DDR2 蛋白结构

重组 DDR2 蛋白

关联疾病

直系同源

热门区域

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DDR2 - discoidin domain receptor tyrosine kinase 2 Gene

关于 DDR2

功能概要

DDR2 基因产物(8)

DDR2 蛋白结构

重组 DDR2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

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