OAS2 - 2'-5'-oligoadenylate synthetase 2 Gene

中文名称：2'-5'-寡聚腺苷酸合成酶 2

种属: Homo sapiens

关于 OAS2

功能概要

该基因编码 2-5A 合成酶家族的成员，这是参与对病毒感染的先天免疫反应的必需蛋白质。编码的蛋白质由干扰素诱导，并在 2'-特异性核苷酸转移反应中使用三磷酸腺苷合成 2',5'-寡聚腺苷酸 (2-5As) 。这些分子激活潜在的 RNase L，导致病毒 RNA 降解和病毒复制的抑制。该基因家族的三个已知成员位于 12 号染色体上的一个簇中。已经描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral Infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]