OAZ1 - ornithine decarboxylase antizyme 1 Gene

中文名称：鸟氨酸脱羧酶抗酶 1

种属: Homo sapiens

同用名: AZ1; AZI; OAZ

关于 OAZ1

功能概要

该基因编码的蛋白质属于鸟氨酸脱羧酶抗酶家族，通过调节细胞内多胺水平在细胞生长和增殖中发挥作用。抗酶的表达需要 +1 核糖体移码，高水平的多胺会增强这种移码。抗酶反过来结合并抑制鸟氨酸脱羧酶 (ODC) ，这是多胺生物合成中的关键酶；这样，就完成了自动调节电路。该基因编码抗酶 1，它是抗酶家族的第一个成员，具有广泛的组织分布，并通过结合并靶向 ODC 进行降解以及抑制多胺摄取来负向调节细胞内多胺水平。抗酶 1 mRNA 包含两个潜在的框内 AUG；在大鼠中进行的研究表明，交替使用两个翻译起始位点会导致 N 末端不同的蛋白质同种型具有不同的亚细胞定位。还注意到该基因的可变剪接转录物变体。[RefSeq 提供，2014 年 12 月]

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key Enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]