2. Gene
  3. OPRK1 - opioid receptor kappa 1 Gene

OPRK1 - opioid receptor kappa 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：阿片受体 kappa 1

种属: Homo sapiens

同用名: KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1

基因 ID: 4986 | 基因类型: protein coding

关于 OPRK1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,225,724-53,251,637 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues.

功能概要

该基因编码阿片受体，它是 7 个跨膜 G 蛋白偶联受体家族的成员。它作为内源性配体的受体，以及各种合成阿片类药物的受体。配体结合导致腺苷酸环化酶活性和神经递质释放的抑制。这种阿片受体在疼痛感知和介导合成阿片类药物的运动减退、镇痛和厌恶作用方面发挥作用。该基因的变异也与酒精依赖和鸦片成瘾有关。已发现该基因编码不同亚型的可变剪接转录物变体。最近的一项研究为该基因的翻译通读提供了证据，并通过使用替代的框内翻译终止密码子表达了额外的 C 末端扩展同种型。[RefSeq 提供，2017 年 12 月]

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRK1 基因产物(3)

mRNA Protein Name
NM_000912.5 NP_000903.2 kappa-type opioid receptor isoform 1
NM_001282904.2 NP_001269833.1 kappa-type opioid receptor isoform 2
NM_001318497.2 NP_001305426.1 kappa-type opioid receptor isoform 1x

OPRK1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
蛋白主名 其他名称

kappa-type opioid receptor

Opiate receptor, kappa-1

OPRK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
31668922
种属内
OPRK1 P41145 APLNR Homo sapiens P35414
BRET
22200678
种属内
OPRK1 P41145 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
种属内
OPRK1 P41145 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
16431922
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Morphine Dependence
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Cocaine Dependence
Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos
Drug Dependence
Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn
Opioid Abuse

Opioid-Related Disorders
Cocaine Abuse

Cocaine-Related Disorders
Pain Agnosia

Analgesia
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome
Retinitis Pigmentosa 44

RP44

Retinitis Pigmentosa, Type 44
Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23

SCA23

Ataxia, Spinocerebellar, Type 23
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Substance Dependence
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Substance Abuse

Substance-Related Disorders

Substance Abuse Problem
Specific Developmental Disorder
Constipation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-116163 ML350 / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus OPRK1 VGNC VGNC:68633
Bos taurus OPRK1 VGNC VGNC:32439
Canis familiaris OPRK1 VGNC VGNC:44133
Macaca mulatta OPRK1 VGNC VGNC:104467
Rattus norvegicus OPRK1 RGD RGD:69426
Mus musculus OPRK1 MGD MGI:97439
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