Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

中文名称：干扰素反应刺激物 cGAMP 相互作用物 1

种属: Rattus norvegicus

同用名: rSTING; Tmem173; RGD1562552

关于 Sting1

功能概要

该基因编码的蛋白可启动 2',3'-环状 GMP-AMP 结合活性。参与细胞对有机环状化合物的反应和 I 型干扰素产生的正向调节。预计位于多种细胞成分中，包括线粒体外膜；细胞质的核周区；和过氧化物酶体。预计是内质网膜的组成部分和内质网-高尔基中间室 (ERGIC) 膜的组成部分。预计在自噬体和内质网膜中具有活性。该基因的人类直系同源基因与婴儿期发病的 STING 相关血管病变有关。与人类 STING1（干扰素反应刺激物 cGAMP 相互作用物 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 2',3'-cyclic GMP-AMP binding activity. Involved in cellular response to organic cyclic compound and positive regulation of type I interferon production. Predicted to be located in several cellular components, including mitochondrial outer membrane; perinuclear region of cytoplasm; and peroxisome. Predicted to be integral component of endoplasmic reticulum membrane and integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane. Predicted to be active in autophagosome and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]