2. Gene
  3. STING1 - stimulator of interferon response cGAMP interactor 1 Gene

STING1 - stimulator of interferon response cGAMP interactor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素反应刺激物 cGAMP 相互作用物 1

种属: Homo sapiens

同用名: ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta

基因 ID: 340061 | 基因类型: protein coding

关于 STING1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,475,533-139,482,758 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 184 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues.

功能概要

该基因编码一种五跨膜蛋白，作为对病毒和细菌感染的先天免疫反应的主要调节剂。编码的蛋白质是一种模式识别受体，可检测细胞溶质核酸并传递激活 I 型干扰素反应的信号。编码的蛋白质还显示通过与 II 型主要组织相容性复合体结合在细胞凋亡信号中发挥作用。该基因的突变是婴儿期发病的 STING 相关血管病变的原因。交替剪接导致多个转录本变体。[RefSeq 提供，2014 年 9 月]

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and Bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

STING1 基因产物(3)

mRNA Protein Name
NM_001301738.2 NP_001288667.1 stimulator of interferon genes protein isoform 2
NM_001367258.1 NP_001354187.1 stimulator of interferon genes protein isoform 3 precursor
NM_198282.4 NP_938023.1 stimulator of interferon genes protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2',3'-cyclic GMP-AMP binding IDA
IDA: 通过直接分析推断
23747010 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
18818105 GOA
enables cyclic-di-GMP binding IDA
IDA: 通过直接分析推断
22705373 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19433799 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18724357 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
19433799 GOA
enables protein kinase binding IDA
IDA: 通过直接分析推断
18818105 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21074459 GOA
enables proton channel activity IDA
IDA: 通过直接分析推断
37535724 GOA
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
23747010 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
23910378 GOA
involved in activation of innate immune response IMP
IMP: 通过突变表型推断
18818105 GOA
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
21074459 GOA
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
30568238 GOA
involved in cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
25636800 GOA
involved in cellular response to exogenous dsRNA IMP
IMP: 通过突变表型推断
18818105 GOA
involved in cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
26669264 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
23910378 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21074459 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
21074459 GOA
involved in innate immune response IMP
IMP: 通过突变表型推断
19433799 GOA
involved in pattern recognition receptor signaling pathway IDA
IDA: 通过直接分析推断
23910378 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18818105 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
18818105 GOA
involved in positive regulation of interferon-beta production IDA
IDA: 通过直接分析推断
21074459 GOA
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
19433799 GOA
involved in positive regulation of macroautophagy IDA
IDA: 通过直接分析推断
30568238 GOA
involved in positive regulation of protein binding IDA
IDA: 通过直接分析推断
18818105 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18818105 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
22394562 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IDA
IDA: 通过直接分析推断
23910378 GOA
acts upstream of protein complex oligomerization IDA
IDA: 通过直接分析推断
35388221 GOA
involved in protein complex oligomerization IDA
IDA: 通过直接分析推断
30842659 GOA
involved in protein localization to endoplasmic reticulum IDA
IDA: 通过直接分析推断
37832545 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Golgi membrane IDA
IDA: 通过直接分析推断
37535724 GOA
located in Golgi membrane IDA
IDA: 通过直接分析推断
29973723 GOA
part of STING complex IPI
IPI: 通过物理相互作用推断
30405246 GOA
located in autophagosome IDA
IDA: 通过直接分析推断
29694889 GOA
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
37832545 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
19433799 GOA
is active in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: 通过直接分析推断
32690950 GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: 通过直接分析推断
30842662 GOA
located in endosome IDA
IDA: 通过直接分析推断
29694889 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
18818105 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STING1 蛋白结构

TMEM173

TMEM173: Transmembrane protein 173 (42 - 338)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
蛋白主名 其他名称

stimulator of interferon genes protein

N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner

endoplasmic reticulum IFN stimulator

endoplasmic reticulum interferon stimulator

mitochondrial mediator of IRF3 activation

stimulator of interferon protein

transmembrane protein 173

STING1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STING1 Q86WV6 LTN1 Homo sapiens O94822
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 SURF4 Homo sapiens O15260
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 SURF4 Homo sapiens O15260
Anti Bait CoIP
29251827
种属内
STING1 Q86WV6 SGPL1 Homo sapiens O95470
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
种属内
STING1 Q86WV6 STAT6 Homo sapiens P42226
Y2H
22000020
种属内
STING1 Q86WV6 STAT6 Homo sapiens P42226
Anti Tag CoIP
22000020
种属内
STING1 Q86WV6 STAT6 Homo sapiens P42226
Confocal
22000020
种属内
STING1 Q86WV6 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434-1
Anti Tag CoIP
18724357
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434-1
Anti Bait CoIP
19416887
种属内
STING1 Q86WV6 RIGI Homo sapiens O95786-1
Anti Tag CoIP
18724357
种属间
STING1 Q86WV6 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Anti Tag CoIP
24622840
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
24622840
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
Anti Tag CoIP
23542348
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
18724357
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
Anti Tag CoIP
19433799
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
X-Ray Diffraction
22728658
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
X-Ray Diffraction
30405246
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
DLS
22728660
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
19433799
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
GMS
22728658
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
X-Ray Diffraction
22728659
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
23542348
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
Comig Non-Denat Gel
19433799
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
X-Ray Diffraction
22728660
种属内
STING1 Q86WV6 TBK1 Homo sapiens Q9UHD2
Anti Bait CoIP
19416887
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
Comigration in SDS
19433799
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
3D-EM
30842659
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
GMS
22728660
种属内
STING1 Q86WV6 STING1 Homo sapiens Q86WV6
Anti Tag CoIP
22312431
种属内
STING1 Q86WV6 SSR2 Homo sapiens P43308
Anti Tag CoIP
18724357
种属内
STING1 Q86WV6 SSR2 Homo sapiens P43308
Y2H
18724357
种属内
STING1 Q86WV6 IFI16 Homo sapiens Q16666
Anti Tag CoIP
20890285
种属内
STING1 Q86WV6 IFI16 Homo sapiens Q16666
Anti Bait CoIP
20890285
种属内
STING1 Q86WV6 TECR Homo sapiens Q9NZ01
Validated Y2H
32296183
种属内
STING1 Q86WV6 IFIT2 Homo sapiens P09913
Anti Bait CoIP
19416887
种属内
STING1 Q86WV6 IFIT2 Homo sapiens P09913
Anti Tag CoIP
19416887
种属内
STING1 Q86WV6 IRAK1 Homo sapiens P51617
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 DDOST Homo sapiens P39656
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
种属内
STING1 Q86WV6 MBOAT7 Homo sapiens Q96N66
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 STT3A Homo sapiens P46977
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 CCDC47 Homo sapiens Q96A33
Anti Tag CoIP
21903422
种属内
STING1 Q86WV6 IFIT1 Homo sapiens P09914
Anti Bait CoIP
19416887
种属内
STING1 Q86WV6 IFIT1 Homo sapiens P09914
Anti Tag CoIP
19416887
种属内
STING1 Q86WV6 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
种属内
STING1 Q86WV6 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
23542348
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
22911572
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434
Confocal
22911572
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
22312431
种属内
STING1 Q86WV6 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
24622840
种属间
STING1 Q86WV6 e1a_ade05 Human adenovirus C P03255
Anti Tag CoIP
26405230
种属间
STING1 Q86WV6 Q99IB8-PRO_0000045601 Hepatitis C virus Q99IB8-PRO_0000045601
Confocal
23542348
种属间
STING1 Q86WV6 P27958-PRO_0000037575 Hepatitis C virus P27958-PRO_0000037575
Anti Tag CoIP
22911572
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STING1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70700 TMEM173 Protein, Human (Sumo-His) Q86WV6 (V155-V341) ≥95%
HY-P70700A TMEM173 Protein, Human (N-Sumo-His) Q86WV6 (V155-V341) ≥95%

关联疾病

疾病名称 别名
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Sting-Associated Vasculopathy, Infantile-Onset

SAVI

Autoinflammatory-Vasculopathy Syndrome
Vascular Skin Disease

Skin Diseases, Vascular

Skin Vascular Disease
Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Autoimmune Disease Of Cardiovascular System
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset
Severe Covid-19
Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis

Niemann-Pick Diseases

Lipoid Histiocytosis

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency Disease

Lipid Histiocytosis

Neuronal Cholesterol Lipidosis

Neuronal Lipidosis

Npd

Sphingomyelinase Deficiency

Niemann-Pick Disease, Type A
Familial Cold Autoinflammatory Syndrome 3

Plaid

Familial Atypical Cold Urticaria

Facu

FCAS3

Antibody Deficiency And Immune Dysregulation, Plcg2-Associated

Plcg2-Associated Antibody Deficiency And Immune Dysregulation

Familial Cold Urticaria With Common Variable Immunodeficiency

Plcg2 Associated Antibody Deficiency And Immune Dysregulation

Antibody Deficiency And Immune Dysregulation Placg2-Associated

Autoinflammatory Syndrome, Cold, Familial, Type 3
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Familial Chilblain Lupus
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112906 C-176 Inhibitor 99.45% 否
HY-138683 STING-IN-3 Inhibitor 99.86% 否
HY-114399 STING ligand-1 99.79% 否
HY-12885C 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt 98.94% 否
HY-RS13917 Sting1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-148643 STING modulator-5 Modulator / 否
HY-RS13916 STING1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13918 Sting1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-163643 STING modulator-7 Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STING1 VGNC VGNC:79674
Mus musculus STING1 MGD MGI:1919762
Canis familiaris STING1 VGNC VGNC:47498
Felis catus STING1 VGNC VGNC:66290
Rattus norvegicus STING1 RGD RGD:1562552
Bos taurus STING1 VGNC VGNC:35997
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