IFIT1 - interferon induced protein with tetratricopeptide repeats 1 Gene

中文名称：干扰素诱导蛋白与四肽重复 1

种属: Homo sapiens

同用名: C56; P56; G10P1; IFI56; ISG56; IFI-56; IFIT-1; IFNAI1; RNM561; IFI-56K

基因 ID: 3434 | 基因类型: protein coding

关于 IFIT1

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,392,623-89,406,487 (from NCBI)

This gene has 2 transcripts (splice variants), 513 orthologues and 4 paralogues. Ubiquitous expression in adrenal (RPKM 10.7), spleen (RPKM 10.7) and 25 other tissues.

功能概要

该基因编码一种含有四肽重复序列的蛋白质，最初被鉴定为在干扰素处理后被诱导产生。编码的蛋白质可以抑制病毒复制和翻译起始。该基因与其他五个密切相关的基因位于 10 号染色体上的一个簇中。该基因在 13 号染色体上有一个假基因。已经观察到编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five Other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

IFIT1 基因产物(5)

mRNA	Protein	Name
NM_001270927.2	NP_001257856.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 2
NM_001270928.2	NP_001257857.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001270929.2	NP_001257858.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001270930.2	NP_001257859.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001548.5	NP_001539.3	interferon-induced protein with tetratricopeptide repeats 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	21642987	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	19008854	GOA
involved in antiviral innate immune response	IEP IEP: 通过表达模式推断	25930096	GOA
involved in cellular response to exogenous dsRNA	IDA IDA: 通过直接分析推断	19008854	GOA
involved in cellular response to type I interferon	IDA IDA: 通过直接分析推断	19008854	GOA
involved in intracellular transport of viral protein in host cell	IDA IDA: 通过直接分析推断	19008854	GOA
involved in negative regulation of helicase activity	IDA IDA: 通过直接分析推断	19008854	GOA
involved in negative regulation of protein binding	IDA IDA: 通过直接分析推断	19416887	GOA
involved in negative regulation of viral genome replication	IMP IMP: 通过突变表型推断	19008854	GOA
involved in positive regulation of viral genome replication	IDA IDA: 通过直接分析推断	19416887	GOA
involved in response to virus	IDA IDA: 通过直接分析推断	19416887	GOA
involved in response to virus	IMP IMP: 通过突变表型推断	21642987	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	19008854	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFIT1 蛋白结构

TPR_12

TPR_1

TPR_2

TPR_1

0
100
200
300
400
478 a.a.

蛋白主名

其他名称

interferon-induced protein with tetratricopeptide repeats 1

interferon, alpha-inducible protein (MW 56kD)

IFIT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IFIT1	P09914	IFIT2	Homo sapiens	P09913	Anti Tag CoIP	21642987
种属间	IFIT1	P09914	E1	Human papillomavirus	P06789	Anti Tag CoIP	19008854
种属间	IFIT1	P09914	E1	Human papillomavirus	P06789	IF	19008854
种属间	IFIT1	P09914	E1	Human papillomavirus	P06789	Anti Bait CoIP	19008854
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	GMS	21642987
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Y2H Array	25416956
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Anti Tag CoIP	21642987
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	BFG-2H	27107012
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Y2H Pooling	16189514
种属内	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Validated Y2H	27107012

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-123805	KIN1400		98.1%	否
HY-RS06560	IFIT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06561	IFIT1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

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IFIT1 - interferon induced protein with tetratricopeptide repeats 1 Gene

关于 IFIT1

功能概要

IFIT1 基因产物(5)

IFIT1 蛋白结构

IFIT1 蛋白互作信息

关联疾病

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IFIT1 - interferon induced protein with tetratricopeptide repeats 1 Gene

关于 IFIT1

功能概要

IFIT1 基因产物(5)

IFIT1 蛋白结构

IFIT1 蛋白互作信息

关联疾病

相关产品

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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