IFIT3 - interferon induced protein with tetratricopeptide repeats 3 Gene

中文名称：干扰素诱导蛋白与四肽重复 3

种属: Homo sapiens

同用名: P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

基因 ID: 3437 | 基因类型: protein coding

关于 IFIT3

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,327,997-89,340,968 (from NCBI)

This gene has 15 transcripts (splice variants), 522 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 22.6), lung (RPKM 21.1) and 24 other tissues.

功能概要

实现相同的蛋白质结合活性。参与细胞凋亡过程的负调控；细胞群增殖的负调节；和对病毒的反应。位于胞质溶胶和线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and response to virus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

IFIT3 基因产物(4)

mRNA	Protein	Name
NM_001031683.4	NP_001026853.1	interferon-induced protein with tetratricopeptide repeats 3 isoform a
NM_001289758.2	NP_001276687.1	interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001289759.2	NP_001276688.1	interferon-induced protein with tetratricopeptide repeats 3 isoform b
NM_001549.6	NP_001540.2	interferon-induced protein with tetratricopeptide repeats 3 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	21642987	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	21190939	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17050680	GOA
involved in response to virus	IMP IMP: 通过突变表型推断	21642987	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17050680	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	21813773	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFIT3 蛋白结构

TPR_12

TPR_1

TPR_11

TPR_8

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

interferon-induced protein with tetratricopeptide repeats 3

CIG49

IFIT3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	IFIT3	O14879	TPM3	Homo sapiens	Q5VU62	Y2H Array	25416956
Intra	IFIT3	O14879	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	IFIT3	O14879	FLJ90650	Homo sapiens	Q0P5U8	Y2H Array	25416956
Intra	IFIT3	O14879	FLJ90650	Homo sapiens	Q0P5U8	Y2H Prey Pooling	25416956
Intra	IFIT3	O14879	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	IFIT3	O14879	TMEM183A	Homo sapiens	Q8IXX5	Y2H Prey Pooling	25416956
Intra	IFIT3	O14879	TMEM183A	Homo sapiens	Q8IXX5	Pull Down	30833792
Intra	IFIT3	O14879	TMEM183A	Homo sapiens	Q8IXX5	Validated Y2H	32296183
Intra	IFIT3	O14879	IFIT1B	Homo sapiens	Q5T764	Anti Tag CoIP	21642987
Intra	IFIT3	O14879	IFIT1B	Homo sapiens	Q5T764	Validated Y2H	32296183
Intra	IFIT3	O14879	IFIT2	Homo sapiens	P09913	Anti Tag CoIP	21642987
Intra	IFIT3	O14879	IFIT2	Homo sapiens	P09913	Y2H Array	31515488
Intra	IFIT3	O14879	TPM3	Homo sapiens	P06753	Y2H	21516116
Intra	IFIT3	O14879	COPS5	Homo sapiens	Q92905	Y2H	17050680
Intra	IFIT3	O14879	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	17050680
Intra	IFIT3	O14879	COPS5	Homo sapiens	Q92905	Pull Down	17050680
Intra	IFIT3	O14879	IFIT1	Homo sapiens	P09914	Y2H Prey Pooling	25416956
Intra	IFIT3	O14879	IFIT1	Homo sapiens	P09914	Anti Tag CoIP	21642987
Intra	IFIT3	O14879	IFIT1	Homo sapiens	P09914	Y2H Array	31515488
Intra	IFIT3	O14879	IFIT1	Homo sapiens	P09914	Validated Y2H	25416956
Intra	IFIT3	O14879	IFIT1	Homo sapiens	P09914	Pull Down	30833792
Intra	IFIT3	O14879	IFIT2	Homo sapiens	Q8IZ03	Validated Y2H	32296183
Intra	IFIT3	O14879	DEUP1	Homo sapiens	Q05D60	Y2H Pooling	16189514
Intra	IFIT3	O14879	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	25416956
Intra	IFIT3	O14879	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06563	IFIT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	IFIT3	VGNC	VGNC:73565
Rattus norvegicus	IFIT3	RGD	RGD:1359681
Bos taurus	IFIT3	VGNC	VGNC:30050
Canis familiaris	IFIT3	VGNC	VGNC:51900

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