2. Gene
  3. IFIT2 - interferon induced protein with tetratricopeptide repeats 2 Gene

IFIT2 - interferon induced protein with tetratricopeptide repeats 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素诱导蛋白与四肽重复 2

种属: Homo sapiens

同用名: P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K

基因 ID: 3433 | 基因类型: protein coding

关于 IFIT2

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,302,046-89,309,271 (from NCBI)

This gene has 15 transcripts (splice variants), 512 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues.

功能概要

启用 RNA 结合活性。参与蛋白结合活性的负调控；凋亡过程的正调控；和对病毒的反应。位于内质网。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

IFIT2 基因产物(1)

mRNA Protein Name
NM_001547.5 NP_001538.4 interferon-induced protein with tetratricopeptide repeats 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19416887 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
19416887 GOA
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
19416887 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21190939 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
19416887 GOA
involved in response to virus IMP
IMP: 通过突变表型推断
21642987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21190939 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
21190939 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFIT2 蛋白结构

TPR_8

TPR_8: Tetratricopeptide repeat (54 - 80)

TPR_11

TPR_11: TPR repeat (249 - 293)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
蛋白主名 其他名称

interferon-induced protein with tetratricopeptide repeats 2

Interferon, alpha-inducible protein (MW 54kD)

IFIT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IFIT2 P09913 IFIT1 Homo sapiens P09914
GMS
21642987
Intra IFIT2 P09913 IFIT1 Homo sapiens P09914
Anti Tag CoIP
33961781
Intra IFIT2 P09913 IFIT1 Homo sapiens P09914
Anti Tag CoIP
21642987
Intra IFIT2 P09913 IFIT1 Homo sapiens P09914
Anti Tag CoIP
28514442
Intra IFIT2 P09913 IFIT3 Homo sapiens O14879
Anti Tag CoIP
33961781
Intra IFIT2 P09913 IFIT3 Homo sapiens O14879
Anti Tag CoIP
28514442
Intra IFIT2 P09913 IFIT3 Homo sapiens O14879
Anti Tag CoIP
21642987
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06562 IFIT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IFIT2 MGD MGI:99449
Felis catus IFIT2 VGNC VGNC:67698
Macaca mulatta IFIT2 VGNC VGNC:106062
Canis familiaris IFIT2 VGNC VGNC:41877
Rattus norvegicus IFIT2 RGD RGD:1307804
Bos taurus IFIT2 VGNC VGNC:30049
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