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  3. P2RY1 - purinergic receptor P2Y1 Gene

P2RY1 - purinergic receptor P2Y1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2Y1

种属: Homo sapiens

同用名: P2Y1; SARCC

基因 ID: 5028 | 基因类型: protein coding

关于 P2RY1

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:152,835,131-152,841,439 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 15 paralogues.

功能概要

该基因的产物属于 G 蛋白偶联受体家族。该家族有几种具有不同药理学选择性的受体亚型，在某些情况下，它们对各种腺苷和尿苷核苷酸有重叠。该受体作为细胞外 ATP 和 ADP 的受体发挥作用。在血小板中，与 ADP 的结合导致通过激活磷脂酶 C 动员细胞内钙离子，改变血小板形状，并可能导致血小板聚集。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of Phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

P2RY1 基因产物(1)

mRNA Protein Name
NM_002563.5 NP_002554.1 P2Y purinoceptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
25822790 GOA
enables G protein-coupled ADP receptor activity IMP
IMP: 通过突变表型推断
9442040 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9671706 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to purine-containing compound IMP
IMP: 通过突变表型推断
9442040 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9442040 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
9442040 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
28154160 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
25822790 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2RY1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 324)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

P2Y purinoceptor 1

ADP receptor

ATP receptor

P2 purinoceptor subtype Y1

platelet ADP receptor

purinergic receptor P2Y, G-protein coupled, 1

suppressing androgen receptor in renal cell carcinoma

P2RY1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra P2RY1 P47900 NHERF1 Homo sapiens O14745
Filter Binding
9671706
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Thrombosis

Thrombosis Of Blood Vessel
Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09914 P2RY1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09915 P2ry1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09916 P2ry1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus P2RY1 RGD RGD:3242
Bos taurus P2RY1 VGNC VGNC:32523
Canis familiaris P2RY1 VGNC VGNC:44213
Macaca mulatta P2RY1 VGNC VGNC:75737
Felis catus P2RY1 VGNC VGNC:68673
Mus musculus P2RY1 MGD MGI:105049
Others P2RY1 NCBI
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