2. Gene
  3. Ptk2b - protein tyrosine kinase 2 beta Gene

Ptk2b - protein tyrosine kinase 2 beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CAKB; Pyk2; CAKbeta; CAK beta

基因 ID: 50646 | 基因类型: protein coding

关于 Ptk2b

功能概要

Enables 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell communication; and positive regulation of cellular biosynthetic process. Located in several cellular components, including dendrite; focal adhesion; and postsynaptic density. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynapse. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast Cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2b 基因产物(1)

mRNA Protein Name
NM_017318.3 NP_059014.2 protein-tyrosine kinase 2-beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-phosphoinositide-dependent protein kinase binding IDA
IDA: 通过直接分析推断
14585963 RGD
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
17188509 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
16945503 RGD
enables glutamate receptor binding IPI
IPI: 通过物理相互作用推断
11239437 RGD
enables neurotransmitter receptor regulator activity IMP
IMP: 通过突变表型推断
11239437 RGD
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
11239437 RGD
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
15814199 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8849729 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10708762 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16945503 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IMP
IMP: 通过突变表型推断
15096502 RGD
involved in actin filament organization IMP
IMP: 通过突变表型推断
17127746 RGD
involved in activation of GTPase activity IMP
IMP: 通过突变表型推断
15158121 RGD
involved in activation of Janus kinase activity IMP
IMP: 通过突变表型推断
11818507 RGD
involved in angiogenesis IMP
IMP: 通过突变表型推断
11739395 RGD
involved in blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
11739395 RGD
involved in cell adhesion IMP
IMP: 通过突变表型推断
11739395 RGD
involved in cell differentiation IEP
IEP: 通过表达模式推断
10964954 RGD
involved in cellular defense response IMP
IMP: 通过突变表型推断
17188509 RGD
involved in epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
16945503 RGD
involved in focal adhesion assembly IMP
IMP: 通过突变表型推断
14585963 RGD
involved in glial cell proliferation IEP
IEP: 通过表达模式推断
11389173 RGD
involved in ionotropic glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
15814199 RGD
involved in long-term synaptic depression IMP
IMP: 通过突变表型推断
20826662 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
11239437 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: 通过突变表型推断
12668584 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17188509 RGD
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
17537919 RGD
involved in neuron projection development IMP
IMP: 通过突变表型推断
10980697 RGD
involved in oocyte maturation IMP
IMP: 通过突变表型推断
17127746 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
14585963 RGD
involved in positive regulation of DNA biosynthetic process IMP
IMP: 通过突变表型推断
21451101 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
15226266 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
15158121 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
16945503 RGD
involved in positive regulation of cell population proliferation IEP
IEP: 通过表达模式推断
11352836 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
11739373 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
11239437 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
21926342 RGD
involved in positive regulation of nitric-oxide synthase activity IMP
IMP: 通过突变表型推断
21926342 RGD
involved in positive regulation of protein metabolic process IMP
IMP: 通过突变表型推断
21451101 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
15158121 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
11239437 RGD
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
12890645 RGD
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
20071509 RGD
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
20071509 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
16120467 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
16120467 RGD
involved in response to cation stress IDA
IDA: 通过直接分析推断
17188509 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
12117546 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
12684223 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
11463795 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
16713446 RGD
involved in response to hydrogen peroxide IPI
IPI: 通过物理相互作用推断
16187300 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
11781137 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
12946883 RGD
involved in response to ischemia IMP
IMP: 通过突变表型推断
15814199 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
15096502 RGD
involved in response to reactive oxygen species IEP
IEP: 通过表达模式推断
15203192 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
11139427 RGD
involved in stress fiber assembly IMP
IMP: 通过突变表型推断
11739395 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NMDA selective glutamate receptor complex IDA
IDA: 通过直接分析推断
11239437 RGD
part of NMDA selective glutamate receptor complex IMP
IMP: 通过突变表型推断
15814199 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
20071509 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
20071509 RGD
located in apical dendrite IDA
IDA: 通过直接分析推断
10583467 RGD
located in axon IDA
IDA: 通过直接分析推断
15128873 RGD
located in cell body IDA
IDA: 通过直接分析推断
10022914 RGD
located in cell cortex IDA
IDA: 通过直接分析推断
17127746 RGD
located in cell projection IDA
IDA: 通过直接分析推断
10022914 RGD
located in dendrite IDA
IDA: 通过直接分析推断
10583467 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
17157995 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22973009 RGD
located in growth cone IDA
IDA: 通过直接分析推断
10583467 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10583467 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16945503 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
22973009 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
11239437 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
20071509 RGD
is active in postsynaptic density, intracellular component IMP
IMP: 通过突变表型推断
20071509 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein-tyrosine kinase 2-beta

CADTK

CAK-beta

FADK 2

PTK2 protein tyrosine kinase 2 beta

PTK2B protein tyrosine kinase 2 beta

calcium-dependent tyrosine kinase

calcium-regulated non-receptor proline-rich tyrosine kinase

cell adhesion kinase beta

focal adhesion kinase 2

proline

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptk2b NCBI NCBI:2185
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