1. Gene
  2. PTK2B - protein tyrosine kinase 2 beta Gene

PTK2B - protein tyrosine kinase 2 beta Gene

中文名称:蛋白酪氨酸激酶 2 β

种属: Homo sapiens

同用名: PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK

基因 ID: 2185 | 基因类型: protein coding

关于 PTK2B

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,310,506-27,459,391 (from NCBI)

This gene has 17 transcripts (splice variants), 269 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 29.2), bone marrow (RPKM 29.0) and 24 other tissues.

功能概要

该基因编码细胞质蛋白酪氨酸激酶,该激酶参与钙诱导的离子通道调节和图谱激酶信号通路的激活。编码的蛋白质可能代表神经肽激活受体或增加钙通量的神经递质与调节神经元活动的下游信号之间的重要信号中间体。编码的蛋白质经历快速酪氨酸磷酸化和激活,以响应细胞内钙浓度的增加、烟碱型乙酰胆碱受体激活、膜去极化或蛋白激酶 C 激活。该蛋白已被证明可结合 CRK 相关底物、nephrocystin、与 FAK 相关的 GTPase 调节剂和 GRB2 的 SH2 结构域。编码的蛋白质是蛋白酪氨酸激酶 FAK 亚家族的成员,但与其他亚家族的激酶缺乏显着的序列相似性。已发现该基因编码两种不同亚型的四种转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of Protein Tyrosine Kinases but lacks significant sequence similarity to kinases from Other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTK2B 基因产物(4)

mRNA Protein Name
NM_004103.4 NP_004094.3 protein-tyrosine kinase 2-beta isoform a
NM_173174.3 NP_775266.1 protein-tyrosine kinase 2-beta isoform a
NM_173175.2 NP_775267.1 protein-tyrosine kinase 2-beta isoform b
NM_173176.3 NP_775268.1 protein-tyrosine kinase 2-beta isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7544443 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8849729 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of Janus kinase activity IMP
IMP: 通过突变表型推断
8670418 GOA
involved in cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
8849729 GOA
involved in cellular response to retinoic acid IMP
IMP: 通过突变表型推断
17910947 GOA
involved in endothelin receptor signaling pathway IMP
IMP: 通过突变表型推断
19086031 GOA
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
15050747 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19880522 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15050747 GOA
involved in negative regulation of myeloid cell differentiation IMP
IMP: 通过突变表型推断
15050747 GOA
involved in negative regulation of potassium ion transport IDA
IDA: 通过直接分析推断
7544443 GOA
involved in peptidyl-tyrosine autophosphorylation IDA
IDA: 通过直接分析推断
9545257 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7544443 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
7544443 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
8670418 GOA
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
18765415 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
18765415 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18765415 GOA
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
18765415 GOA
involved in positive regulation of endothelial cell migration IDA
IDA: 通过直接分析推断
21245381 GOA
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
17910947 GOA
involved in positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
7544443 GOA
involved in regulation of cell adhesion IMP
IMP: 通过突变表型推断
19086031 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
19086031 GOA
involved in regulation of ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
19880522 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
8670418 GOA
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
21245381 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
18765415 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
18765415 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19880522 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
18765415 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTK2B 蛋白结构

FERM_M

FERM_M: FERM central domain (145 - 253)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (426 - 678)

Focal_AT

Focal_AT: Focal adhesion targeting region (870 - 1007)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1009 a.a.
蛋白主名 其他名称

protein-tyrosine kinase 2-beta

CAK-beta

PTK2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTK2B Q14289 RHOU Homo sapiens Q7L0Q8
Pull Down
18086875
种属内
PTK2B Q14289 RHOU Homo sapiens Q7L0Q8
Anti Tag CoIP
18086875
种属内
PTK2B Q14289 NPHP4 Homo sapiens O75161
Anti Bait CoIP
15661758
种属内
PTK2B Q14289 FYN Homo sapiens P06241
Pull Down
10867021
种属内
PTK2B Q14289 FYN Homo sapiens P06241
Pull Down
32707033
种属内
PTK2B Q14289 FYN Homo sapiens P06241
Y2H Fragment Pooling
31413325
种属内
PTK2B Q14289 SRC Homo sapiens P12931
Pull Down
10521452
种属内
PTK2B Q14289 SRC Homo sapiens P12931
CoIP
11149930
种属间: 跨种属相互作用 种属内: 同种属相互作用

PTK2B 抗体

目录号 产品名 应用 反应物种
HY-P80877 PYK2 Antibody (YA682) WB, IHC-P Human

关联疾病

疾病名称 别名
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones

Cone-Rod Dystrophy 5

CORD5

Dystrophy, Cone-Rod, Type 5

Glioma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Retinal Degeneration

Degeneration Of Retina

Mixed Cell Adenoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PTK2B RGD RGD:628758
Bos taurus PTK2B VGNC VGNC:33519
Macaca mulatta PTK2B VGNC VGNC:76593
Canis familiaris PTK2B VGNC VGNC:45159
Felis catus PTK2B VGNC VGNC:69153
Mus musculus PTK2B MGD MGI:104908
Others PTK2B NCBI