REG3A - regenerating family member 3 alpha Gene

中文名称：重生的家族成员 3 alpha

种属: Homo sapiens

同用名: HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III

基因 ID: 5068 | 基因类型: protein coding

关于 REG3A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,157,006-79,159,753 (from NCBI)

This gene has 6 transcripts (splice variants), 788 orthologues and 5 paralogues. Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8).

功能概要

该基因编码可能参与细胞增殖或分化的胰腺分泌蛋白。它与 C 型凝集素超家族具有相似性。在胰腺炎症和肝癌发生过程中观察到该基因表达增强。成熟蛋白还作为具有抗菌活性的抗菌蛋白发挥作用。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2014 年 11 月]

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with Antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

REG3A 基因产物(3)

mRNA	Protein	Name
NM_002580.3	NP_002571.1	regenerating islet-derived protein 3-alpha precursor
NM_138937.3	NP_620354.1	regenerating islet-derived protein 3-alpha precursor
NM_138938.3	NP_620355.1	regenerating islet-derived protein 3-alpha precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hormone activity	IDA IDA: 通过直接分析推断	22727489	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	24256734	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of inflammatory response to wounding	IDA IDA: 通过直接分析推断	27830702	GOA
involved in negative regulation of keratinocyte differentiation	IDA IDA: 通过直接分析推断	22727489	GOA
involved in positive regulation of keratinocyte proliferation	IDA IDA: 通过直接分析推断	22727489	GOA
involved in response to wounding	IDA IDA: 通过直接分析推断	22727489	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in extracellular space	IDA IDA: 通过直接分析推断	22727489	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

REG3A 蛋白结构

Lectin_C

0
100
175 a.a.

蛋白主名

其他名称

regenerating islet-derived protein 3-alpha

PAP homologous protein

REG3A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	REG3A	Q06141	ACTB	Homo sapiens	P60709	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	28514442
种属内	REG3A	Q06141	ACTC1	Homo sapiens	P68032	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
种属内	REG3A	Q06141	ACTB	Homo sapiens	P60709	Anti Tag CoIP	28514442
种属内	REG3A	Q06141	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
种属内	REG3A	Q06141	KLHL22	Homo sapiens	Q53GT1	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	ACTBL2	Homo sapiens	Q562R1	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	CMAS	Homo sapiens	Q8NFW8	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	ACTBL2	Homo sapiens	Q562R1	Anti Tag CoIP	28514442
种属内	REG3A	Q06141	PUS7	Homo sapiens	Q96PZ0	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	REG3A	Homo sapiens	Q06141	Crosslink	24256734
种属内	REG3A	Q06141	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	SERPINB8	Homo sapiens	P50452	Anti Tag CoIP	33961781
种属内	REG3A	Q06141	REG3A	Homo sapiens	Q06141	3D-EM	24256734
种属内	REG3A	Q06141	CMSS1	Homo sapiens	Q9BQ75	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 REG3A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76002	REG-3 alpha/REG3A Protein, Human (HEK293, His)	Q06141-1 (E27-D175)	≥95%

关联疾病

疾病名称

别名

Pancreatitis

Mumps Pancreatitis

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11820	REG3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	REG3A	RGD	RGD:3254
Mus musculus	REG3A	NCBI	NCBI:19694
Others	REG3A	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

REG3A - regenerating family member 3 alpha Gene

关于 REG3A

功能概要

REG3A 基因产物(3)

REG3A 蛋白结构

REG3A 蛋白互作信息

重组 REG3A 蛋白

关联疾病

直系同源

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REG3A - regenerating family member 3 alpha Gene

关于 REG3A

功能概要

REG3A 基因产物(3)

REG3A 蛋白结构

REG3A 蛋白互作信息

重组 REG3A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z