KLHL22 - kelch like family member 22 Gene

中文名称：kelch 样家族成员 22

种属: Homo sapiens

同用名: KELCHL

基因 ID: 84861 | 基因类型: protein coding

关于 KLHL22

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,441,519-20,495,795 (from NCBI)

This gene has 12 transcripts (splice variants), 194 orthologues and 54 paralogues. Ubiquitous expression in brain (RPKM 3.8), thyroid (RPKM 3.7) and 25 other tissues.

功能概要

启用 14-3-3 蛋白结合活性。参与多个过程，包括细胞蛋白质代谢过程；细胞对亮氨酸的反应；和有丝分裂纺锤体组装检查点信号。位于几种细胞成分中，包括细胞质；细胞间桥；和微管细胞骨架。 Cul3-RING 泛素连接酶复合物的一部分。与溶酶体和细胞核共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables 14-3-3 protein binding activity. Involved in several processes, including cellular protein metabolic process; cellular response to leucine; and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including cytosol; intercellular bridge; and microtubule Cytoskeleton. Part of Cul3-RING ubiquitin Ligase complex. Colocalizes with lysosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

KLHL22 基因产物(1)

mRNA	Protein	Name
NM_032775.4	NP_116164.2	kelch-like protein 22

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IPI IPI: 通过物理相互作用推断	29769719	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23455478	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	29769719	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell division	IMP IMP: 通过突变表型推断	19995937	GOA
involved in cellular response to L-leucine	IMP IMP: 通过突变表型推断	29769719	GOA
involved in cellular response to amino acid stimulus	IDA IDA: 通过直接分析推断	29769719	GOA
involved in mitotic sister chromatid segregation	IMP IMP: 通过突变表型推断	23455478	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: 通过突变表型推断	23455478	GOA
involved in negative regulation of autophagy	IMP IMP: 通过突变表型推断	29769719	GOA
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	36394357	GOA
involved in positive regulation of T cell activation	IDA IDA: 通过直接分析推断	33109719	GOA
involved in positive regulation of T cell mediated immune response to tumor cell	IDA IDA: 通过直接分析推断	33109719	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	29769719	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: 通过突变表型推断	29769719	GOA
involved in positive regulation of cell growth	IMP IMP: 通过突变表型推断	29769719	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	29769719	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	29769719	GOA
involved in protein monoubiquitination	IDA IDA: 通过直接分析推断	23455478	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	36394357	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul3-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	19995937	GOA
located in centrosome	IDA IDA: 通过直接分析推断	23455478	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	23455478	GOA
located in cytosol	IDA IDA: 通过直接分析推断	29769719	GOA
colocalizes with lysosome	IDA IDA: 通过直接分析推断	29769719	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	23455478	GOA
colocalizes with nucleus	IDA IDA: 通过直接分析推断	29769719	GOA
located in polar microtubule	IDA IDA: 通过直接分析推断	23455478	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLHL22 蛋白结构

BTB

BACK

Kelch_6

Kelch_1

Kelch_3

Kelch_1

0
100
200
300
400
500
634 a.a.

蛋白主名

其他名称

kelch-like protein 22

kelch-like 22

KLHL22 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KLHL22	Q53GT1	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	37788672
种属内	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	33961781
种属内	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	28514442
种属内	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Lumier	25036637

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mixed Fibrolamellar Hepatocellular Carcinoma

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07363	KLHL22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KLHL22	RGD	RGD:1306288
Bos taurus	KLHL22	VGNC	VGNC:30651
Felis catus	KLHL22	VGNC	VGNC:82548
Mus musculus	KLHL22	MGD	MGI:1337995
Canis familiaris	KLHL22	VGNC	VGNC:42457

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLHL22 - kelch like family member 22 Gene

关于 KLHL22

功能概要

KLHL22 基因产物(1)

KLHL22 蛋白结构

KLHL22 蛋白互作信息

关联疾病

直系同源

热门区域

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KLHL22 - kelch like family member 22 Gene

关于 KLHL22

功能概要

KLHL22 基因产物(1)

KLHL22 蛋白结构

KLHL22 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z