NUDCD3 - NudC domain containing 3 Gene

中文名称：含 NudC 域 3

种属: Homo sapiens

同用名: NudCL

关于 NUDCD3

功能概要

该基因的产物起到维持动力蛋白中间链稳定的作用。该基因产物的耗尽导致动力蛋白中间链的聚集和降解，动力蛋白复合物从着丝粒、纺锤体微管和纺锤体两极的错误定位，以及纺锤体两极的伽马微管蛋白的丢失。蛋白质在间期定位于高尔基体，并且蛋白质水平在 G1/S 转换后增加。[RefSeq 提供，2008 年 7 月]

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]