Gsk3a - glycogen synthase kinase 3 alpha Gene

中文名称：糖原合酶激酶 3α

种属: Rattus norvegicus

关于 Gsk3a

功能概要

该基因编码的蛋白可启动蛋白激酶 A 催化亚基结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括树突发育的负调控；神经元凋亡过程的正向调控；和蛋白质磷酸化。位于细胞质和微管中。帕金森病的生物标志物。该基因的人类直系同源物与肌萎缩侧索硬化症有关。与人 GSK3A（糖原合成酶激酶 3 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase A catalytic subunit binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of dendrite development; positive regulation of neuron apoptotic process; and protein phosphorylation. Located in cytoplasm and microtubule. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]