2. Gene
  3. F11R - F11 receptor Gene

F11R - F11 receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：F11 受体

种属: Homo sapiens

同用名: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1

基因 ID: 50848 | 基因类型: protein coding

关于 F11R

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,995,211-161,021,152 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 14 paralogues. Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues.

功能概要

紧密连接代表上皮或内皮细胞片中细胞间粘附的一种模式，在细胞周围形成连续密封，并作为物理屏障防止溶质和水自由通过细胞旁空间。由该免疫球蛋白超家族基因成员编码的蛋白质是上皮细胞紧密连接装配的重要调节因子。此外，编码的蛋白质可以作为 (1) 呼肠孤病毒的受体， (2) 整合素 LFA1 的配体，参与白细胞迁移，以及 (3) 血小板受体。已经鉴定出编码相同蛋白质的多个 5' 可变剪接变体，但尚未确定其生物学有效性。[RefSeq 提供，2008 年 7 月]

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the Integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

F11R 基因产物(6)

mRNA Protein Name
NM_001348091.2 NP_001335020.1 junctional adhesion molecule A isoform 6 precursor
NM_001382727.1 NP_001369656.1 junctional adhesion molecule A isoform 7 precursor
NM_001382730.1 NP_001369659.1 junctional adhesion molecule A isoform 8 precursor
NM_001382733.1 NP_001369662.1 junctional adhesion molecule A isoform 9 precursor
NM_001382734.1 NP_001369663.1 junctional adhesion molecule A isoform 10 precursor
NM_016946.6 NP_058642.1 junctional adhesion molecule A isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
23885123 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
11812992 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15344881 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
14749337 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actomyosin structure organization IMP
IMP: 通过突变表型推断
23885123 GOA
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
14749337 GOA
involved in cellular response to mechanical stimulus IDA
IDA: 通过直接分析推断
26985018 GOA
involved in establishment of endothelial intestinal barrier IGI
IGI: 通过遗传相互作用推断
23885123 GOA
involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
23885123 GOA
involved in intestinal absorption IMP
IMP: 通过突变表型推断
23885123 GOA
involved in leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
11812992 GOA
involved in memory T cell extravasation IDA
IDA: 通过直接分析推断
11812992 GOA
involved in negative regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
25753039 GOA
involved in positive regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
26985018 GOA
involved in positive regulation of establishment of endothelial barrier IMP
IMP: 通过突变表型推断
26985018 GOA
involved in positive regulation of platelet aggregation IDA
IDA: 通过直接分析推断
15344881 GOA
involved in protein localization to bicellular tight junction IMP
IMP: 通过突变表型推断
25753039 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
23885123 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
15344881 GOA
involved in regulation of bicellular tight junction assembly IMP
IMP: 通过突变表型推断
25753039 GOA
involved in regulation of cell shape IDA
IDA: 通过直接分析推断
15344881 GOA
involved in regulation of cytoskeleton organization IMP
IMP: 通过突变表型推断
25753039 GOA
involved in regulation of membrane permeability IMP
IMP: 通过突变表型推断
23885123 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
23885123 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11812992 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
15344881 GOA
located in tight junction IMP
IMP: 通过突变表型推断
14749337 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

F11R 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (30 - 121)

Ig_2

Ig_2: Immunoglobulin domain (140 - 227)

  • 0
  • 100
  • 200
  • 299 a.a.
蛋白主名 其他名称

junctional adhesion molecule A

junctional adhesion molecule 1

F11R 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
F11R Q9Y624 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
种属内
F11R Q9Y624 CAMLG Homo sapiens P49069
Y2H Array
32296183
种属内
F11R Q9Y624 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
F11R Q9Y624 SGTA Homo sapiens O43765
Y2H
21516116
种属内
F11R Q9Y624 SGTA Homo sapiens O43765
Validated Y2H
25416956
种属内
F11R Q9Y624 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 F11R 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70948 JAM-A/CD321 Protein, Human (HEK293, His) Q9Y624-1 (S28-V238) ≥95%

F11R 抗体

目录号 产品名 应用 反应物种
HY-P83280 Junctional Adhesion Molecule 1 Antibody (YA3025) WB, ICC/IF, IP Human

关联疾病

疾病名称 别名
Nemaline Myopathy 4

Cap Myopathy 2

NEM4

Nemaline Myopathy 4, Autosomal Dominant

Nemaline Myopathy, Type 4

CAPM2

Cap Disease

Cap Myopathy Tpm2-Related

Tpm2-Related Nemaline Myopathy

Tpm2-Related Cap Myopathy

Myopathy, Nemaline, Type 4

Cap Myopathy
Purulent Acute Otitis Media

Acute Suppurative Otitis Media

Acute Or Subacute Suppurative Otitis Media

Acute Or Subacute Purulent Otitis Media
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris F11R VGNC VGNC:56143
Macaca mulatta F11R VGNC VGNC:72272
Mus musculus F11R MGD MGI:1321398
Bos taurus F11R VGNC VGNC:50010
Felis catus F11R VGNC VGNC:109510
Rattus norvegicus F11R RGD RGD:621842
Others F11R NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z