1. Gene
  2. TAOK3 - TAO kinase 3 Gene

TAOK3 - TAO kinase 3 Gene

中文名称:TAO 激酶 3

种属: Homo sapiens

同用名: DPK; JIK; hKFC-A; MAP3K18

基因 ID: 51347 | 基因类型: protein coding

关于 TAOK3

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,149,801-118,372,907 (from NCBI)

This gene has 19 transcripts (splice variants), 299 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 12.0), prostate (RPKM 9.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种丝氨酸/苏氨酸蛋白激酶,可激活 p38/MAPK14 应激激活的 MAPK 级联,但抑制 MAPK8/JNK 级联的基础活性。编码的蛋白质是 STE20 样激酶的 GCK 亚家族的成员。[RefSeq 提供,2016 年 10 月]

The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]

TAOK3 基因产物(12)

mRNA Protein Name
NM_001346487.2 NP_001333416.1 serine/threonine-protein kinase TAO3 isoform a
NM_001346488.2 NP_001333417.1 serine/threonine-protein kinase TAO3 isoform b
NM_001346489.2 NP_001333418.1 serine/threonine-protein kinase TAO3 isoform b
NM_001346490.2 NP_001333419.1 serine/threonine-protein kinase TAO3 isoform c
NM_001346491.2 NP_001333420.1 serine/threonine-protein kinase TAO3 isoform d
NM_001346492.2 NP_001333421.1 serine/threonine-protein kinase TAO3 isoform d
NM_001346493.2 NP_001333422.1 serine/threonine-protein kinase TAO3 isoform e
NM_001346494.2 NP_001333423.1 serine/threonine-protein kinase TAO3 isoform f
NM_001346495.2 NP_001333424.1 serine/threonine-protein kinase TAO3 isoform f
NM_001346496.2 NP_001333425.1 serine/threonine-protein kinase TAO3 isoform g
NM_001346497.2 NP_001333426.1 serine/threonine-protein kinase TAO3 isoform g
NM_016281.4 NP_057365.3 serine/threonine-protein kinase TAO3 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11278723 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10559204 GOA
enables transferase activity IDA
IDA: 通过直接分析推断
10559204 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
17396146 GOA
involved in MAPK cascade IMP
IMP: 通过突变表型推断
10924369 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17396146 GOA
involved in negative regulation of JNK cascade IDA
IDA: 通过直接分析推断
10559204 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
10924369 GOA
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
11278723 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
17396146 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
10559204 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10559204 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
11278723 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAOK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (28 - 277)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase TAO3

CTCL-associated antigen HD-CL-09

TAOK3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAOK3 Q9H2K8 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
11278723
种属内
TAOK3 Q9H2K8 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
11278723
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TAOK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77222 TAOK3 Protein, Human (sf9, His) Q9H2K8 (M1-D411) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus TAOK3 VGNC VGNC:35597
Canis familiaris TAOK3 VGNC VGNC:47104
Macaca mulatta TAOK3 VGNC VGNC:81593
Felis catus TAOK3 VGNC VGNC:80496
Mus musculus TAOK3 MGD MGI:3041177
Rattus norvegicus TAOK3 RGD RGD:1562861
Others TAOK3 NCBI